Table 5 Cardiac Events by TKIs Drug Name
TKIs | QTc (ms) | MI | HF | Stroke | Mortality | Cardiac Mortality | |
|---|---|---|---|---|---|---|---|
Mean ± SEM | ≥ 450,n(%) | n (%) | n (%) | n (%) | n (%) | N (%) | |
Alectinib (N = 1) | 555 | 1 (100) | 1 (100) | 1 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Axitinib (N = 2) | 426.5 ± 22.5 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (50) | 0 (0.0) |
Carbozantinib (N = 4) | 453.5 ± 18.8 | 2 (50.0) | 2 (50.0) | 0 (0.0) | 0 (0.0) | 1 (25.0) | 0 (0.0) |
Crizotinib (N = 6) | 450.0 ± 34.2 | 2 (33.3) | 2(33.3) | 0 (0.0) | 0 (0.0) | 2 (33.3) | 1 (16.7) |
Dasatinib (N = 6) | 527.8 ± 90.3 | 6 (100) | 2(33.3) | 1(16.67) | 1(16.6) | 1 (16.67) | 1 (16.67) |
Erlotinib (N = 12) | 469.6 ± 48.8 | 8 (66.67) | 2(16.6) | 2(16.67) | 0 (0.0) | 5 (41.67) | 1 (8.33) |
Ibrutinib (N = 20) | 459.3 ± 45.9 | 12 (60.0) | 5(25.0) | 5 (25.0) | 2(10.0) | 7 (35.0) | 0 (0.0) |
Imatinib (N = 27) | 460.6 ± 38.4 | 17 (63.0) | 4(14.8) | 9(33.3) | 0 (0.0) | 12 (44.4) | 3 (11.1) |
Lapatinib (N = 4) | 465.0 ± 27.4 | 2 (50) | 1 (25.0) | 1 (25.0) | 0 (0.0) | 2 (50.0) | 0 (0.0) |
Lenvatinib (N = 2) | 507 ± 32.0 | 2 (100) | 1 (50.0) | 0 (0.0) | 1 (50) | 1 (50) | 0 (0.0) |
Midostaurin (N = 3) | 528.3 ± 80.1 | 3 (100) | 0 (0.0) | 1(33.33) | 0 (0.0) | 1 (33.33) | 0 (0.0) |
Nilotinib (N = 8) | 492.6 ± 40.2 | 6 (75.0) | 6(75.0) | 2 (25.0) | 2 (25.0) | 2 (25.0) | 0 (0.0) |
Pazopanib (N = 12) | 456.9 ± 26.5 | 7 (58.3) | 4(33.30) | 5 (41.7) | 2 (16.7) | 7 (58.3) | 2 (16.7) |
Ponatinib (N = 1) | 548 | 1 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (100) | 0 (0.0) |
Regorafenib (N = 1) | 624 | 1 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (100) | 0 (0.0) |
Ruxolitinib (N = 6) | 494.7 ± 61.7 | 4 (66.7) | 0 (0.0) | 1(16.7) | 0 (0.0) | 3 (50.0) | 2 (33.3) |
Sorafenib (N = 32) | 492.2 ± 50.0 | 24 (75.0) | 10(31.3) | 4 (12.5) | 1(3.1) | 15 (46.9) | 0 (0.0) |
Sunitinib (N = 11) | 457.5 ± 22.2 | 6 (54.5) | 2 (18.2) | 3(27.3) | 0 (0.0) | 2 (18.2) | 0 (0.0) |
Tofacitinib (N = 1) | 417 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Trametinib (N = 2) | 412.5 ± 12.5 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (100) | 0 (0.0) |