Articles

Etiology and management of hypertension in patients with cancer

The pathophysiology of hypertension and cancer are intertwined. Hypertension has been associated with an increased likelihood of developing certain cancers and with higher cancer-related mortality. Moreover, v...

Authors: Turab Mohammed, Meghana Singh, John G. Tiu and Agnes S. Kim

Treatment of corticosteroid refractory immune checkpoint inhibitor myocarditis with Infliximab: a case series

Glucocorticoid treatment remains the cornerstone of therapy for immune checkpoint inhibitor (ICI) myocarditis, but data supporting the use of additional immunotherapy for steroid refractory cases remains limit...

Authors: Robert S. Zhang, Allison Padegimas, Kathleen M. Murphy, Peter T. Evans, Carli J. Peters, Christopher M. Domenico, Mahesh K. Vidula, Paul J. Mather, Marisa Cevasco, Roger B. Cohen, Joseph R. Carver and Rupal P. O’Quinn

Management strategies and clinical outcomes in breast cancer patients who develop left ventricular dysfunction during trastuzumab therapy

Trastuzumab reduces risk of breast cancer recurrence but carries risk of cardiotoxicity that may be reversible upon treatment cessation and institution of left ventricular (LV) enhancement therapies (LVETx). W...

Authors: Ren Jie Robert Yao, Jordan Gibson, Christine Simmons and Margot K. Davis

Insurance disparity in cardiovascular mortality among non-elderly cancer survivors

Insurance status plays a vital role in cancer diagnosis, treatments and survival. Cancer patients have higher cardiovascular disease (CVD) mortality than the general population.

Authors: Tiantian Shi, Changchuan Jiang, Cenjing Zhu, Fangcheng Wu, Irma Fotjhadi and Stuart Zarich

Newly diagnosed cardiovascular disease in patients treated with immune checkpoint inhibitors: a retrospective analysis of patients at an academic tertiary care center

Immune checkpoint inhibitors (ICIs) are a novel class of anticancer agents that have demonstrated clinical response for both solid and hematological malignancies. ICIs are associated with development of immune...

Authors: Nida Waheed, Michael G. Fradley, David L. DeRemer, Ahmad Mahmoud, Chintan P. Shah, Taimour Y. Langaee, Gloria P. Lipori, Keith March, Carl J. Pepine, Rhonda M. Cooper-DeHoff, Yonghui Wu and Yan Gong

Risk of malignancy long after acute coronary syndrome in selected urban and rural areas and comparison with smoking risk: the ABC-7* study on Heart Disease

Increased cancer risk has been reported in patients with acute coronary syndrome (ACS).

Authors: Giuseppe Berton, Heba T. Mahmoud, Rosa Palmieri, Fiorella Cavuto, Rocco Cordiano, Elisabetta Lorenzon and Francesco Bagato

Competing mortality risks: predicted cardiovascular disease risk versus predicted risk of breast cancer mortality in patients receiving adjuvant chemotherapy in a single Irish center

Due to advances in care, most women diagnosed with breast cancer do not die from the disease itself. Instead, cardiovascular disease (CVD) remains the most frequent cause of death. Many breast cancer patients ...

Authors: Lisa Prior, Hannah Featherstone, David O’Reilly, Killian Nugent, Marvin Lim, John McCaffrey, Michaela J Higgins and Catherine M. Kelly

High intensity exercise during breast cancer chemotherapy - effects on long-term myocardial damage and physical capacity - data from the OptiTrain RCT

Adjuvant systemic breast cancer treatment improves disease specific outcomes, but also presents with cardiac toxicity. In this post-hoc exploratory analysis of the OptiTrain trial, the effects of exercise on c...

Authors: Josefin Ansund, Sara Mijwel, Kate A. Bolam, Renske Altena, Yvonne Wengström, Eric Rullman and Helene Rundqvist

Plasma proteome profiling of cardiotoxicity in patients with diffuse large B-cell lymphoma

Cardiovascular toxicity is a notorious complication of doxorubicin (DXR) therapy for diffuse large B-cell lymphoma (DLBCL). Although surveillance of well-known biological markers for cardiovascular disease (CV...

Authors: Charlott Mörth, Amal Abu Sabaa, Eva Freyhult, Christina Christersson, Jamileh Hashemi, Nashmil Hashemi, Masood Kamali-Moghaddam, Daniel Molin, Martin Höglund, Anna Eriksson and Gunilla Enblad

Echocardiographic myocardial strain analysis describes subclinical cardiac dysfunction after craniospinal irradiation in pediatric and young adult patients with central nervous system tumors

Craniospinal irradiation (CSI) is part of the treatment of central nervous system (CNS) tumors and is associated with cardiovascular disease in adults. Global myocardial strain analysis including longitudinal ...

Authors: Hugo R. Martinez, Ralph Salloum, Erin Wright, Lauren Bueche, Philip R. Khoury, Justin T. Tretter and Thomas D. Ryan

Baseline global longitudinal strain predictive of anthracycline-induced cardiotoxicity

Cancer therapy-related cardiac dysfunction (CTRD) is a major source of morbidity and mortality in long-term cancer survivors. Decreased GLS predicts decreased left ventricular ejection fraction (LVEF) in patie...

Authors: Raquel Araujo-Gutierrez, Kalyan R. Chitturi, Jiaqiong Xu, Yuanchen Wang, Elizabeth Kinder, Alpana Senapati, L. Bindu Chebrolu, Mahwash Kassi and Barry H. Trachtenberg

Healthcare disparities in cardio oncology: patients receive same level of surveillance regardless of race at a safety net hospital

Cardiotoxicity remains a dreaded complication for patients undergoing chemotherapy with human epidermal growth factor (HER)-2 receptor antagonists and anthracyclines. Though many studies have looked at racial ...

Authors: Crystal B. Chen, Raj K. Dalsania and Eman A. Hamad

A virtual-hybrid approach to launching a cardio-oncology clinic during a pandemic

As cardiovascular disease is a leading cause of death in cancer survivors, the new subspecialty of Cardio-Oncology has emerged to address prevention, monitoring, and management of cardiovascular toxicities to ...

Authors: Sherry-Ann Brown, Sahishnu Patel, David Rayan, Svetlana Zaharova, Mingqian Lin, Tarek Nafee, Bipin Sunkara, Ragasnehith Maddula, James MacLeod, Krishna Doshi, Joshua Meskin, David Marks and Jorge Saucedo

Book review: cancer and the heart

Authors: Umesh C. Sharma and Saraswati Pokharel

A case report: rapid progression of coronary atherosclerosis in a patient taking Targretin (Bexarotene)

Anti-neoplastic drugs have made major advancements in oncology, however they are not without cardiovascular consequences. We present a patient with cutaneous T-cell lymphoma receiving Targretin therapy who pre...

Authors: Sean DeAngelo, Kailyn I. Mann, Muhammad Abdulbasit, Amy Ahnert and Deborah W. Sundlöf

Takotsubo syndrome induced by brachytherapy in a patient with endocervical adenocarcinoma

Takotsubo syndrome (TTS), also known as stress cardiomyopathy, apical ballooning syndrome and broken heart syndrome, is characterized by acute-onset chest pain, electrocardiographic (ECG) abnormalities and rev...

Authors: Aline Cristini Vieira, Mauricio Fernando Silva Almeida Ribeiro, Julianne Lima, Jacob Sessim Filho, Heloisa de Andrade Carvalho and Max Senna Mano

The prevalence of iron deficiency and anemia and their impact on survival in patients at a cardio-oncology clinic

Iron deficiency (ID) and anemia are common in both heart failure (HF) and cancer patients and are associated with poor quality of life and survival. The aims of this study were (1) to evaluate the prevalence, ...

Authors: E. Čiburienė, J. Čelutkienė, S. Aidietienė, G. Ščerbickaitė and A. R. Lyon

Perspectives on the COVID-19 pandemic impact on cardio-oncology: results from the COVID-19 International Collaborative Network survey

Re-allocation of resources during the COVID-19 pandemic has resulted in delays in care delivery to patients with cardiovascular disease and cancer. The ability of health care providers to provide optimal care ...

Authors: Diego Sadler, Jeanne M. DeCara, Joerg Herrmann, Anita Arnold, Arjun K. Ghosh, Husam Abdel-Qadir, Eric H. Yang, Sebastian Szmit, Nausheen Akhter, Monika Leja, Carolina Maria Pinto Domingues Carvalho Silva, Jayant Raikhelkar, Sherry-Ann Brown, Susan Dent, Rupal O’Quinn, Franck Thuny…

Aerobic and resistance exercise improves Reynolds risk score in overweight or obese breast cancer survivors

Breast cancer survivors have double the risk of mortality from cardiovascular disease than age-matched women without a cancer history. Reynolds risk score (RRS) is a validated algorithm for the assessment of c...

Authors: Kyuwan Lee, Nathalie Sami, Debu Tripathy, Wendy Demark-Wahnefried, Mary K. Norris, Kerry S. Courneya and Christina M. Dieli-Conwright

Clinical impact of interruption in adjuvant Trastuzumab therapy in patients with operable HER-2 positive breast cancer

Trastuzumab-induced cardiotoxicity (TIC) can lead to early discontinuation of adjuvant therapy, however there is limited evidence on long-term survival outcomes in patients with operable human epidermal growth...

Authors: Sagar Sardesai, Jasmine Sukumar, Mahmoud Kassem, Marilly Palettas, Julie Stephens, Evan Morgan, Daniel Addison, Ragavendra Baliga, Daniel G. Stover, Jeffrey VanDeusen, Nicole Williams, Mathew Cherian, Maryam Lustberg, Robert Wesolowski and Bhuvaneswari Ramaswamy

In ®Entresto we trust

Sacubitril/Valsartan (S/V) is a novel and remarkably effective opportunity to treat heart failure with reduced ejection fraction (HFrEF). However, patients with HFrEF induced by cancer therapy were a priori ex...

Authors: Massimiliano Camilli, Marco Giuseppe Del Buono, Pierantonio Menna and Giorgio Minotti

Use of Sacubitril/valsartan in patients with cardio toxicity and heart failure due to chemotherapy

Cancer therapy-related cardiac dysfunction (CTRCD) is a critical problem with an impact on both oncological and cardiovascular prognosis, especially when it prevents patients from receiving cancer treatment. S...

Authors: Vanesa Gregorietti, Teresa Lopez Fernandez, Diego Costa, Elías Ortega Chahla and Andrés J. Daniele

Early- and late anthracycline-induced cardiac dysfunction: echocardiographic characterization and response to heart failure therapy

Anthracycline-induced cardiac dysfunction (ACD) is a notorious side effect of anticancer treatment. It has been described as a phenomenon of a continuous progressive decline of cardiac function, eventually lea...

Authors: Janine A. M. Kamphuis, Marijke Linschoten, Maarten J. Cramer, Pieter A. Doevendans, Folkert W. Asselbergs and Arco J. Teske

A case of irreversible bradycardia after rituximab therapy for diffuse large B-cell lymphoma

This is a case of a middle-aged woman with underlying cardiac conduction system with episodes of AV Wenckebach, who subsequently developed significant AV conduction system abnormalities after receiving one sta...

Authors: Nway Le Ko Ko, Nareg Minaskeian and Hicham Z. El Masry

Severe combined cardiac and neuromuscular toxicity from immune checkpoint blockade: an institutional case series

Immune checkpoint inhibition is part of standard systemic management for many advanced malignancies. Toxicities from this treatment approach are unpredictable, though usually reversible with management per est...

Authors: Puja Arora, Laura Talamo, Patrick Dillon, Ryan D. Gentzler, Trish Millard, Michael Salerno, Craig L. Slingluff Jr and Elizabeth M. Gaughan

An overview of a different type of cardio-oncology gathering: summary of the COMP (cardio-oncology multidisciplinary practice) meeting held in Houston Texas, January 2020

An innovative Cardio-Oncology meeting was held in Houston, Texas in January of 2020. This gathering was intended to broaden the scope of Cardio-Oncology to include major presentations by clinicians and researc...

Authors: Anecita P. Fadol, Nicolas L. Palaskas, Michael S. Ewer and Anita Deswal

#CardioOncology: Twitter chat as a mechanism for increasing awareness of heart health for cancer patients

Consideration of heart health for cancer survivors is increasingly important, as improved cancer survivorship has resulted in a growing number of survivors affected by cardiovascular disease. However, there is...

Authors: Claire C. Conley, Neha G. Goyal and Sherry-Ann Brown

Acute myocardial infarction caused by tumor embolus originating from upper tract urothelial carcinoma: a case report

Coronary emboli from malignant tumors rarely cause acute myocardial infarction. We report the case of a patient with tumor embolism from an upper tract urothelial carcinoma that caused acute myocardial infarct...

Authors: Taku Yasui, Yohei Okuda, Wataru Shioyama, Toru Oka, Tatsuya Nishikawa, Risa Kamada, Koji Hatano, Kazuo Nishimura and Masashi Fujita

Carfilzomib induced cardiotoxicity in a multiple myeloma patient

Proteasome inhibitors such as carfilzomib are indicated in multiple myeloma patients showing relapse and/or refractoriness of clonal activity. However, this therapy has been associated with a significant incid...

Authors: Arnold Méndez-Toro, Cándida Díaz-Brochero and Estivalis Acosta-Gutiérrez

Approaches to management of cardiovascular morbidity in adult cancer patients – cross-sectional survey among cardio-oncology experts

In cardio-oncology, a range of clinical dilemmas can be identified where high-quality evidence for management is still lacking. The aim of this project was to study clinical practices and expert approaches to ...

Authors: E. Hedayati, A. Papakonstantinou, A. Månsson-Broberg, J. Bergh, L. Hubbert and R. Altena

Resistance to antihypertensive drugs targeting Renin-Angiotensin-Aldosterone-System in cancer patients: a case series

Hypertension impacts overall prognosis in cancer patients. There are no specific recommendations for its management in these patients. We report a case series of 5 cancer patients with suboptimal BP lowering a...

Authors: Mishita Goel, Rajiv Sunil Varandani and Tochukwu M. Okwuosa

Healthcare utilization and hospital variation in cardiac surveillance during breast cancer treatment: a nationwide prospective study in 5000 Dutch breast cancer patients

Various breast cancer (BC) treatments, such as chemotherapy and targeted therapies, increase cardiotoxicity-risk and lead to premature ischemic heart disease and heart failure among survivors. Reducing this ad...

Authors: Yvonne Koop, Saloua El Messaoudi, Hester Vermeulen, Angela H. E. M. Maas and Femke Atsma

Atlas-based measures of left ventricular shape may improve characterization of adverse remodeling in anthracycline-exposed childhood cancer survivors: a cross-sectional imaging study

Adverse cardiac remodeling is an important precursor to anthracycline-related cardiac dysfunction, however conventional remodeling indices are limited. We sought to examine the utility of statistical atlas-der...

Authors: Hari K. Narayan, Ronghui Xu, Nickolas Forsch, Sachin Govil, David Iukuridze, Lanie Lindenfeld, Eric Adler, Sanjeet Hegde, Adriana Tremoulet, Bonnie Ky, Saro Armenian, Jeffrey Omens and Andrew D. McCulloch

Gender disparity in cardiovascular mortality following radiation therapy for Hodgkin’s lymphoma: a systematic review

Radiation-induced coronary artery disease (R-CAD) has become an increasingly recognized phenomenon. Although the clinical relationship between radiation therapy and CAD risk is well known, there is minimal inv...

Authors: Yaser Khalid, Michael Fradley, Neethi Dasu, Kirti Dasu, Ankit Shah and Adam Levine

Quantitative assessment of cardiovascular autonomic impairment in cancer survivors: a single center case series

Cardiovascular autonomic dysfunction in cancer survivors is poorly understood.

Authors: Benjamin Noor, Shannel Akhavan, Michael Leuchter, Eric H. Yang and Olujimi A. Ajijola

Prediction of doxorubicin cardiotoxicity by early detection of subclinical right ventricular dysfunction

Doxorubicin remains one of the most common causes of cardiotoxicity in patients with lymphoma, leading to significant morbidity and mortality. Early decline in left ventricular (LV) ejection fraction predicts ...

Authors: Maria Isabel Camara Planek, Ahmad Manshad, Kyaw Hein, Mohamad Hemu, Fatima Ballout, Rajiv Varandani, Parameswaran Venugopal and Tochukwu Okwuosa

Practical and cost-effective model to build and sustain a cardio-oncology program

Cardio-Oncology (CO) is a new subspecialty that thrives mostly in large academic quaternary centers. This study describes how to establish a successful cardio-oncology program, with limited resources, in order...

Authors: Diego Sadler, Chakra Chaulagain, Beatrice Alvarado, Robert Cubeddu, Elizabeth Stone, Thomas Samuel, Bruno Bastos, David Grossman, Chieh-Lin Fu, Evan Alley, Arun Nagarajan, Timmy Nguyen, Wesam Ahmed, Leah Elson and Zeina Nahleh

Outcomes after transcatheter aortic valve replacement in cancer survivors with prior chest radiation therapy: a systematic review and meta-analysis

Cancer survivors with prior chest radiation therapy (C-XRT) frequently present with aortic stenosis (AS) as the first manifestation of radiation-induced heart disease. They are considered high-risk for surgica...

Authors: Meer Rabeel Zafar, Syed Farrukh Mustafa, Timothy W. Miller, Talal Alkhawlani and Umesh C. Sharma

The hypertensive effect of sorafenib is abolished by sildenafil

Contrasting to the well documented tyrosine kinase inhibitor (TKI)-induced hypertension, little is known on their intrinsic vasomotor effects. We investigated the vasomotor effects of sorafenib, a widely used ...

Authors: Hubert Dabiré, Fatou Dramé, Nelly Cita and Bijan Ghaleh

Cardiac MRI utilizing late gadolinium enhancement (LGE) and T1 mapping in the detection of radiation induced heart disease

Radiotherapy has been associated with late dose-dependent cardiovascular toxicity. In this cross-sectional pilot study, radiation dose distributions were correlated with areas of localized and diffuse myocardi...

Authors: Anthony Ricco, Alexander Slade, Justin M. Canada, John Grizzard, Franklin Dana, Leila Rezai Gharai, Keith Neiderer, Armando Vera, Antonio Abbate and Elisabeth Weiss

Evaluating anthracycline cardiotoxicity associated single nucleotide polymorphisms in a paediatric cohort with early onset cardiomyopathy

Anthracyclines are a mainstay of chemotherapy. However, a relatively frequent adverse outcome of anthracycline treatment is cardiomyopathy. Multiple genetic studies have begun to dissect the complex genetics u...

Authors: Timothy N. McOwan, Lauren A. Craig, Anne Tripdayonis, Kathy Karavendzas, Michael M. Cheung, Enzo R. Porrello, Rachel Conyers and David A. Elliott

A case report: high dose melphalan as a conditioning regimen for multiple myeloma induces sinus arrest

High dose melphalan is commonly used as a conditioning regimen for autologous stem cell transplantation in multiple myeloma. There are reports of adverse cardiac events with melphalan manifested by supraventri...

Authors: Liang-Liang Ma, Ying Liu, Si-Xun Jia, Hai-Chen Lv, Mei-Yun Fang and Yun-Long Xia

Increased C-reactive protein is associated with the severity of thoracic radiotherapy-induced cardiomyopathy

Irradiation of the heart during cancer radiotherapy is associated with a dose-dependent risk of heart failure. Animal studies have demonstrated that irradiation leads to an inflammatory response within the hea...

Authors: Justin M. Canada, Georgia K. Thomas, Cory R. Trankle, Salvatore Carbone, Hayley Billingsley, Benjamin W. Van Tassell, Ronald K. Evans, Ryan Garten, Elisabeth Weiss and Antonio Abbate

Hospitalized cancer patients with acquired long QT syndrome-a matched case-control study

Our recent study has revealed that many hospitalized patients with acquired long QT syndrome (ALQTS) are cancer patients. This study aims to determine the risk factors and outcomes of hospitalized cancer patie...

Authors: Yajuan Lin, Haixu Yu, Fei Liu, Cheng Chen, Yanli Zhang, Binhao Wang, Yiheng Yang, Ying Liu, Li Zhang and Yunlong Xia

Detection of subclinical cardiotoxicity in sarcoma patients receiving continuous doxorubicin infusion or pre-treatment with dexrazoxane before bolus doxorubicin

Continuous infusion of doxorubicin or dexrazoxane pre-treatment prior to bolus doxorubicin are proven strategies to protect against doxorubicin-induced cardiotoxicity. Recently, global longitudinal peak systol...

Authors: Jieli Li, Hui-Ming Chang, Jose Banchs, Dejka M. Araujo, Saamir A. Hassan, Elizabeth A. Wagar, Edward T. H. Yeh and Qing H. Meng

Validation of the Spanish version of the MD Anderson symptom inventory – heart failure (MDASI-HF-Spanish) module

The lack of a validated symptom assessment instrument in Spanish for patients with cancer and heart failure (HF) can affect the care and impede the recruitment and participation of Spanish-speaking patients in...

Authors: Anecita Fadol, Joaquin Buitrago, Maria C. Diaz, Valerie Shelton, Carolyn Harty and Tito R. Mendoza

Strategies to prevent anthracycline-induced cardiotoxicity in cancer survivors

Cancer diagnostics and therapies have improved steadily over the last few decades, markedly increasing life expectancy for patients at all ages. However, conventional and newer anti-neoplastic therapies can ca...

Authors: Neha Bansal, M. Jacob Adams, Sarju Ganatra, Steven D. Colan, Sanjeev Aggarwal, Rudolf Steiner, Shahnawaz Amdani, Emma R. Lipshultz and Steven E. Lipshultz

Antecedent cancer in Takotsubo syndrome predicts both cardiovascular and long-term mortality

Takotsubo syndrome (TTS), primarily an acute myocardial inflammatory condition engendered by catecholamine exposure, is associated with similar long-term mortality rates to those of patients with acute myocard...

Authors: Thanh H. Nguyen, Jeanette Stansborough, Gao J. Ong, Sven Surikow, Timothy J. Price and John D. Horowitz

Influence of breast reconstruction on technical aspects of echocardiographic image acquisition compared with physician-assessed image quality

Assessment of cardiac function after treatment for breast cancer relies on interval evaluation of ventricular function through echocardiography. Women who undergo mastectomy more frequently choose to undergo b...

Authors: Joaquin Duarte Ow, Mohamad Hemu, Anel Yakupovich, Parva Bhatt, Hannah Gaddam, Nicole Prabhu, Ibtihaj Fughhi, Melody Cobleigh, Melissa Tracy, Louis Fogg and Tochukwu Okwuosa

Effects of dexrazoxane on doxorubicin-related cardiotoxicity and second malignant neoplasms in children with osteosarcoma: a report from the Children’s Oncology Group

Dexrazoxane protects from lower-cumulative-dose doxorubicin cardiotoxicity, but the effect of dexrazoxane in children with sarcoma treated with higher-cumulative-dose doxorubicin is unknown.

Authors: Lisa M. Kopp, Richard B. Womer, Cindy L. Schwartz, David H. Ebb, Vivian I. Franco, David Hall, Donald A. Barkauskas, Mark D. Krailo, Holcombe E. Grier, Paul A. Meyers, Leonard H. Wexler, Neyssa M. Marina, Katherine A. Janeway, Richard Gorlick, Mark L. Bernstein and Steven E. Lipshultz