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Table 3 The effect of risk factors on all-cause mortality – Univariate and multiple logistic regression analysis

From: Effect of myocardial dysfunction in cardiac morbidity and all cause mortality in childhood cancer subjects treated with anthracycline therapy

Risk Factorsa, b Unadjusted OR 95 % CI p-value Adjusted OR 95 % CI p-value
Years post-chemo 0.62 0.54, 0.70 <0.001 0.62 0.54, 0.71 <0.001
Age at Diagnosis (yrs) 1.05 1.01, 1.10 0.02 0.94 0.87, 1.02 0.12
Gender 0.69 0.42, 1.16 0.16 --- --- ---
Cumulative dose 3.77 2.12, 6.71 <0.001 3.17 1.14, 8.85 0.03
Radiation to chest 1.32 0.66, 2.67 0.43 --- --- ---
Vinca Alkaloids 0.32 0.19, 0.54 <0.001 0.37 0.13, 1.08 0.07
Previous SF < 29 % 4.52 2.62, 7.79 <0.001 6.54 2.40, 17.81 <0.001
BMT 4.21 2.19, 8.09 <0.001 5.22 1.57, 17.37 0.007
Previous heart disease 1.66 0.76, 3.61 0.20 --- --- ---
Cardio-protective drugs 0.71 0.21, 2.39 0.58 --- --- ---
Solid Tumor Diagnosis 3.2 1.94, 5.42 <0.001 4.13 1.72, 9.87 0.001
  1. aRisk factors for cardiotoxicity include increased length of post-chemotherapy interval (years), younger age at diagnosis, female gender, total cumulative dose ≥240 mg/m2, radiation therapy to the chest, treatment with vinca alkaloids, previous shortening fraction < 29 %, bone marrow transplant, previous heart disease, non-use of cardio-protective drugs, solid tumor diagnosis
  2. bThe 7 significant risk factors upon univariate analysis were selected as covariates for the multiple logistic regression model (increased length post-chemotherapy interval, younger age at diagnosis, total cumulative dose anthracyclines > 240 mg/m2, use of vinca alkaloids, previous SF < 29 %, BMT, and solid tumor diagnosis)