Table 2 Heart pathology scores in SHHF rats based on evaluation of hematoxylin and eosin (HE) stained sections
From: The interplay between genetic background and sexual dimorphism of doxorubicin-induced cardiotoxicity
Sex | Treatment | Myocyte vacuolization; loss of myofibrils score | Coagulation necrosis; coagulative myocytolysis score | Interstitial cell proliferation; inflammation score | Cumulative heart score |
|---|---|---|---|---|---|
Male | Saline | 1 (1–2) | 1 (1–1) | 2 (1–2) | 4 (3–5) |
|  | DOX | 2 (1–2) | 1 (0–2) | 3 (1–3) | 5 (3–7) |
Female | Saline | 1 (0–2) | 0 (0–1) | 0 (0–1)* | 2 (0–3) |
|  | DOX | 1 (1–2) | 1 (0–1) | 1 (1–2) | 3 (2–5) |