Fig. 1
From: Crizotinib inhibits hyperpolarization-activated cyclic nucleotide-gated channel 4 activity
ECGs of isolated mouse hearts before and after crizotinib. a Representative ECG tracing, as described in Methods, recorded from an isolated mouse heart prior to exposure to crizotinib. RR and QT intervals are indicated as shown, and time is shown on x axis. (Note: time scale = 0–2000 msec for panels a-b and 0–10 s for panel c). b-c Representative ECG tracings recorded from the same isolated mouse heart as in (a) when exposed to 1 μmol/L (b) and 10 μmol/L crizotinib (c) respectively