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Table 3 Coronary Heart Disease Factors by Thymic Irradiation Group

From: Risk of coronary events 55 Years after Thymic irradiation in the Hempelmann cohort

Variable

% Irradiated

(n)

% Non-Irradiated

P-value

(Ir vs. Non-ir)

Bivariate Rate Ratio

MI (95%CI)a

P-valueb

Adjusted Rate Ratio for MI

(95%CI)c

Bivariate Rate Ratio

CHD (95%CI)a

P-valueb

Adjusted Rate Ratio for CHD

(95%CI)c

Thymic Irradiation

  

< 0.001

 

> 0.50

  

0.29

 

 Yes

100

–

 

1.08 (0.82–1.42)

 

0.98 (0.74–1.30)

1.17 (0.94–1.39)

 

1.07 (0.86–1.32)

  No

–

100

 

Ref

  

Ref

  

Sex

  

< 0.001

 

<  0.001

  

<  0.001

 

 Male

57.9

50.7

 

2.75 (2.03–3.78)

 

1.97 (1.44–2.72)

2.68 (2.13–3.41)

 

1.88 (1.48–2.40

 Female

42.1

49.3

 

Ref

  

Ref

  

 Attained Aged (years, mean)

57.5

57.5

1.00

1.11 (1.10–1.12)

Per decade

<  0.001

 

1.12 (1.11–1.13)

<  0.001

1.10 (1.09–1.11)

Smokee

  

0.58

 

<  0.001

  

<  0.001

 

 Ever

52.6 (1397)

51.8 (2504)

 

1.79 (1.32–2.48)

 

1.49 (1.09–2.07)

1.77 (1.39–2.28)

 

1.41 (1.10–1.82)

 Unknown

13.2 (350)

13.5 (651)

       

 Never

34.2 (909)

34.7 (1678)

 

Ref

  

Ref

  

Diabetesf

  

0.49

 

<  0.001

  

<  0.001

 

 Yes

11.1 (145)

10.2 (181)

 

3.43 (2.39–4.84)

 

1.80 (1.24–2.59)

3.27 (2.44–4.32)

 

1.80 (1.34–2.39)

 Unknown

0.4 (5)

0.2 (4)

       

 No

88.6 (1154)

89.5 (1583)

 

Ref

  

Ref

  

Dyslipidemiaf

  

0.10

 

<  0.001

  

<  0.001

 

 Yes

54.6 (712)

51.7 (914)

 

6.42 (3.99–11.04)

 

4.04 (2.48–7.01)

6.16 (4.23–9.34)

 

4.01 (2.78–6.24)

 Unknown

0.4 (5)

0.3 (5)

       

 No

45.0 (586)

48.0 (849)

 

Ref

  

Ref

  

Hypertensionf

  

0.57

 

<  0.001

  

<  0.001

 

 Yes

40.4 (527)

39.4 (698)

 

3.96 (2.76–5.80)

 

2.11 (1.45–3.13)

4.06 (3.04–5.50)

 

2.29 (1.70–3.13)

 Unknown

0.5 (6)

0.6 (10)

       

 No

59.1 (770)

60.0 (1060)

 

Ref

  

Ref

  

Family history MI or sudden deathf

  

0.14

 

0.001

NS

 

< 0.001

NS

 Yes

21.9 (285)

24.2 (429)

 

1.78 (1.25–2.52)

  

1.66 (1.25–2.19)

  

 Unknown

19.0 (248)

17.6 (311)

       

 No

59.1 (770)

58.1 (1027)

 

Ref

  

Ref

  

Hypothyroide

  

0.003

 

0.50

–

 

< 0.001

NS

 Yes

4.3 (114)

3.0 (146)

 

1.06 (0.52–1.89)

  

1.18 (0.71–1.85)

  

 Unknown

15.3 (407)

14.3 (689)

       

 No

80.3 (2135)

82.7 (3998)

 

Ref

  

Ref

  
  1. Bolded p-values are for univariate comparisons that are potentially significant and thus tested in building multivariate models
  2. a Relative risk and 95% CI in this column calculated separately for each variable in Poisson regression model stratified by attained age and sex. Sex evaluated in a model adjusted by attained age only
  3. bp-value for likelihood ratio test for model fit compared to model with attained age and sex only
  4. cAdjusted rate ratios for variables from most parsimonious multivariate Poisson regression model stratified by attained age and sex
  5. dAt time of last follow-up
  6. eVariable information collected on past surveys as well as 2004–08 survey
  7. fVariables information only collected in 2004–2008 survey so numbers are for respondents to most recent survey only
  8. -- Not significant in univariate analysis by treatment group or outcome status so placement in multivariate model not attempted
  9. NS Potentially significant in univariate analysis stratified by attained age and sex (when appropriate), but does not add significantly to model as determined by Likelihood ratio test versus most parsimonious model
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Cardio-Oncology

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