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Table 2 Baseline characteristics of the included studies

From: Outcomes after transcatheter aortic valve replacement in cancer survivors with prior chest radiation therapy: a systematic review and meta-analysis

 

Groups

Dijos [16]

Bouleti [17]

Gajanana [18]

Agrawal [10]

Demographics

 Age

C-XRT

68.3 ± 1.7*

73.4 (61.3–83.6)

76 ± 13*

81.64 ± 7.81

Control

82.5 ± 6.6

73.3 (67.8–83.1)

82 ± 8

82.67 ± 7.98

 Male sex

C-XRT

7 (36.84)

13 (50)

10 (23) *

29 (38.66)

Control

101 (56.4)

13 (50)

583 (51)

291 (54.39)

 BMI ((kg/m2)

C-XRT

25.9 ± 5.1

21.9 (18.7–24.9)*

29.1 ± 8.9

27.14 ± 6.32

Control

27.1 ± 5.7

27.9 (22.9–29.8)

28.2 ± 8.6

28.11 ± 5.98

Comorbid conditions

 Hypertension

C-XRT

9 (47.31) *

12 (46)

37 (86)

66 (88)

Control

139 (77.6)

22 (85)

1062 (93)

476 (88.9)

 Diabetes mellitus

C-XRT

1 (5.3) *

0 (0)

13 (31)

31 (41.3

Control

56 (31.3)

7 (2)

392 (34)

176 (32.5)

 Coronary Artery disease

C-XRT

9 (47.3)

14 (54)

3 (7)

50 (66.67)

Control

104 (58.1)

12 (46)

193 (17)

307 (57.3)

 Prior stroke

C-XRT

0 (0)

1 (4)

4 (9)

10 (13.33)

Control

11 (6.1)

2 (8)

125 (12)

53 (9.9)

Risk scores and Echocardiographic characteristics

 STS score (%)

C-XRT

NR

5.0 (2.9–6.1)

7 ± 4

8.1 (5.1–11)

Control

4.7 (3.0–8.7)

8 ± 5

8.1 (5.3–11)

 LVEF (%)

C-XRT

57 ± 11.3

60 (45–60)

53 ± 11

55.65 ± 12.40

Control

53.8 ± 14.8

60 (45–60)

52 ± 13

54.46 ± 13.1

 Mean AV gradient (mm Hg)

C-XRT

47.9 ± 15.5

47 (41–57)

41 ± 9*

43.06 ± 13.67

Control

45.9 ± 15.8

52 (46–65)

45 ± 13

40.87 ± 15.48

  1. Values presented as n (%), mean (SD), or median (25-75th percentiles)
  2. (*) indicates p valve < 0.05 for patients in the radiation group (C-XRT) compared to the control group
  3. BMI Body mass index, STS Surgical Thoracic Society risk score, LVEF Left ventricular ejection fraction, AV Aortic valve, NR Not reported