Fig. 1
From: The hypertensive effect of sorafenib is abolished by sildenafil
Comparative concentration-response curves (a) of sorafenib (full circles), acetylcholine (Ach, full squares), and sodium nitroprusside (SNP, full diamonds) in endothelium intact rat aortic rings precontracted by NA (3.10− 6 M). Concentration-response curves of sorafenib (b), Ach (c) and SNP (d) in endothelium intact (full circles) and denuded (full squares) rat aortic rings precontracted by NA (3.10− 6 M). Each point is the mean ± SEM of 6–15 rats. * P < 0.001 vs 10− 10 M; †††P < 0.001 vs endothelium intact ring. ANOVA for repeated measures