Fig. 3
From: The hypertensive effect of sorafenib is abolished by sildenafil
Concentration response curves of sorafenib in endothelium intact (E+) and endothelium denuded (E-) rat aortic rings, in the presence of solvent (Solv, full circles), ouabain (OUA, full diamonds, Panel a) or the combination of OUA plus ODQ (full diamonds, Panel b). Each point is the mean ± SEM of 7–8 rats. * P < 0.001 vs 10− 10 M; †††P < 0.001 vs Solvent. ANOVA for repeated measures