A case of irreversible bradycardia after rituximab therapy for diffuse large B-cell lymphoma

Cardio-Oncology

Table 1 Naranjo Adverse Drug Reaction Probability Scale

Question	Yes	No	Do not know	Score
Are there previous conclusive reports on this reaction?	+ 1	0	0	+ 1
Did the adverse event appear after the suspected drug was administered?	+ 2	− 1	0	+ 2
Did the adverse event improve when the drug was discontinued or a specific antagonist was administered?	+ 1	0	0	0
Did the adverse event reappear when the drug was readministered?	+ 2	−1	0	0
Are there alternative causes that could on their own have caused the reaction?	−1	+ 2	0	0
Did the reaction reappear when a placebo was given?	−1	+ 1	0	0
Was the drug detected in blood or other fluids in concentrations known to be toxic?	+ 1	0	0	0
Was the reaction more severe when the dose was increased or less severe when the dose was decreased?	+ 1	0	0	0
Did the patient have a similar reaction to the same or similar drugs in any previous exposure?	+ 1	0	0	0
Was the adverse event confirmed by any objective evidence?	+ 1	0	0	0
Total score				3

ISSN: 2057-3804