Skip to main content

Table 1 Naranjo Adverse Drug Reaction Probability Scale

From: A case of irreversible bradycardia after rituximab therapy for diffuse large B-cell lymphoma

Question Yes No Do not know Score
Are there previous conclusive reports on this reaction? + 1 0 0 + 1
Did the adverse event appear after the suspected drug was administered? + 2 − 1 0 + 2
Did the adverse event improve when the drug was discontinued or a specific antagonist was administered? + 1 0 0 0
Did the adverse event reappear when the drug was readministered? + 2 −1 0 0
Are there alternative causes that could on their own have caused the reaction? −1 + 2 0 0
Did the reaction reappear when a placebo was given? −1 + 1 0 0
Was the drug detected in blood or other fluids in concentrations known to be toxic? + 1 0 0 0
Was the reaction more severe when the dose was increased or less severe when the dose was decreased? + 1 0 0 0
Did the patient have a similar reaction to the same or similar drugs in any previous exposure? + 1 0 0 0
Was the adverse event confirmed by any objective evidence? + 1 0 0 0
Total score     3