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Table 2 Demographic, laboratory, and standard echocardiographic measures at early and late timepoints after craniospinal radiation (see text for definition of terms)

From: Echocardiographic myocardial strain analysis describes subclinical cardiac dysfunction after craniospinal irradiation in pediatric and young adult patients with central nervous system tumors

 

Early

Late

N

20a

34b

Age (years)

13.3 ± 9.6

21.7 ± 10.4

Time since therapy completion (years)

0.2 ± 0.3

13.1 ± 8.8

SBP (mmHg)

105.4 ± 10.3

115.2 ± 16.1

LVEDD (mm)

4.0 ± 0.6

3.9 ± 0.6

LVFS (%)

32.6 ± 5.4

34.4 ± 3.8

LVEF (%)

62.3 ± 6.5

60.9 ± 4.5

Presence of diabetes mellitusc

0 (0%)

1 (3%)

Presence of hypertensiond

1 (5%)

2 (6%)

Patient on cardiac medication(s)e

1 (5%)

3 (9%)

Hemoglobin (g/dL)f

11.3 ± 1.5

13.5 ± 2.3

Creatinine (mg/dL)f

0.5 ± 0.1

0.7 ± 0.3

  1. aN available for analysis: LVEDD = 19; LVEF = 15; all other = 20
  2. bN available for analysis: SBP and LVSF = 33; LVEDD and LVEF = 30; hemoglobin = 29; creatinine = 27; all other = 34
  3. cPatients with a diagnosis of diabetes mellitus documented in the chart or on medication to control diabetes at the time of the echocardiogram
  4. dPatients with systolic blood pressure > 95%ile for age or on antihypertensive medication at the time of the echocardiogram
  5. ePatients on cardiac medication(s) at time of echocardiogram, including angiotensin converting enzyme inhibitor, angiotensin receptor blocker, beta blocker, calcium channel blocker, or mineralocorticoid receptor antagonist
  6. fLaboratory data collected from the electronic medical record for the value closest in time to the echocardiogram but no greater than ± 8 weeks
  7. LV Left ventricular, LVEDD Left ventricular diastolic dimension, LVEF Left ventricular ejection fraction, LVFS Left ventricular fractional shortening, SBP Systolic blood pressure