Table 2 Crude and adjusted incidence rate of non-hematological cancers according to AS status and age
AS status | Events (n) | Follow-up (person-years) | Incidence rate (Per 1000 p-y) | Crude HR (95% CI) | Adjusted HRa (95% CI) |
|---|---|---|---|---|---|
Entire study population (n = 105,897) | |||||
Mod or Severe AS (n = 7013) | 677 | 29,800 | 22.7 | 1.58 (1.46–1.71) | 0.93 (0.86–1.01) |
No AS (n = 98,884) | 10,028 | 733,067 | 13.7 | Reference | Reference |
Age lowest quartile: 20–49.7 years (n = 26,476) | |||||
Mod or Severe AS (n = 183) | 12 | 1330 | 9.0 | 2.26 (1.28–3.99) | 1.91 (1.08–3.39) |
No AS (n = 26,293) | 887 | 223,466 | 4.0 | Reference | Reference |
Age second quartile: 49.7–63 years (n = 26,477) | |||||
Mod or Severe AS (n = 558) | 58 | 3820 | 15.2 | 1.24 (0.95–1.60) | 1.15 (0.88–1.49) |
No AS (n = 25,919) | 2689 | 218,792 | 12.3 | Reference | Reference |
Age third quartile: 63–74.7 years (n = 26,475) | |||||
Mod or Severe AS (n = 1610) | 176 | 8345 | 21.1 | 1.02 (0.87–1.18) | 0.96 (0.82–1.12) |
No AS (n = 24,865) | 3575 | 175,370 | 20.4 | Reference | Reference |
Age highest quartile: > 74.7 years (n = 26,469) | |||||
Mod or Severe AS (n = 4662) | 431 | 16,306 | 26.4 | 1.00 (0.91–1.11) | 0.99 (0.89–1.10) |
No AS (n = 21,807) | 2877 | 115,438 | 24.9 | Reference | Reference |