Table 2 Univariate and multivariable analysis of MACE after start of treatment

Treatment group: RT + ADT vs RT only

1.01 (0.78–1.30)

0.969

0.95 (0.73–1.25)

0.722

Age (years): 70 & over vs below 70

1.41 (1.12–1.78)

0.004

1.35 (1.05–1.72)

0.018

Ethnic group: Malays vs Chinese

1.66 (1.04–2.65)

0.033

1.53 (0.93–2.51)

0.095

Ethnic group: Indians vs Chinese

2.15 (1.38–3.35)

0.001

1.79 (1.11–2.87)

0.016

Ethnic group: Others vs Chinese

1.37 (0.62–3.04)

0.436

1.57 (0.69–3.58)

0.282

Gleason score: 7 vs 6 or less

0.99 (0.75–1.30)

0.919

Gleason score: 8–10 vs 6 or less

1.03 (0.74–1.43)

0.859

ISUP grade: 2 vs 1

1.03 (0.76–1.40)

0.851

ISUP grade: 3 vs 1

0.92 (0.64–1.31)

0.636

ISUP grade: 4 vs 1

0.96 (0.61–1.50)

0.856

ISUP grade: 5 vs 1

1.08 (0.74–1.56)

0.699

D’Amico risk: Intermediate vs Low

0.87 (0.61–1.26)

0.472

D’Amico risk: High vs Low

0.99 (0.71–1.39)

0.966

Previous history of MACE: Yes vs No

2.05 (1.61–2.63)

< 0.001

1.75 (1.21–2.53)

0.003

Baseline CVD risk factor: ≥1 vs 0

2.53 (1.64–3.92)

< 0.001

1.73 (1.08–2.76)

0.022

Baseline metformin: Yes vs No

1.94 (1.46–2.56)

< 0.001

1.56 (1.15–2.10)

0.004

Baseline insulin: Yes vs No

3.10 (1.46–6.56)

0.003

1.53 (0.68–3.45)

0.310

Baseline statins: Yes vs No

1.61 (1.28–2.03)

< 0.001

1.21 (0.92–1.58)

0.174

Baseline antiplatelet: Yes vs No

1.61 (1.21–2.15)

0.001

0.78 (0.53–1.15)

0.213

Baseline anticoagulant: Yes vs No

1.82 (0.87–3.83)

0.113

Surgery for IHD at baseline: Yes vs No

1.99 (1.47–2.71)

< 0.001

1.15 (0.76–1.75)

0.513

Radiation intent: Definitive vs Salvage

1.51 (0.98–2.32)

0.063