From: Outcomes of malignancy in adults with congenital heart disease: a single center experience
Predictor variable | Mortality (n = 16) | MACCE (n = 40) | ||
---|---|---|---|---|
OR (95% CI) | p | OR (95% CI) | p | |
Male sex | 0.87 (0.28 - 2.70) | 0.811 | 1.03 (0.38 - 2.79) | 0.952 |
ACHD complexity | 1.22 (0.54 - 2.72) | 0.632 | 1.52 (0.75 - 3.09) | 0.246 |
Single ventricle circulation | 1.24 (0.33 - 4.62) | 0.748 | 6.02 (1.23 - 29.37) | 0.011 |
Prior cardiac surgery | 5.53 (0.67 - 45.81) | 0.054 | 1.985 (0.62 - 6.34) | 0.246 |
Number of fluoroscopic procedures | 1.02 (0.74 - 1.40) | 0.928 | 1.46 (1.04 - 2.06) | 0.018 |
History of arrhythmia | 3.82 (1.15 - 12.67) | 0.028 | 2.90 (1.02 - 8.17) | 0.039 |
Systemic ventricular dysfunction at baseline | 2.5 (0.49 - 12.76) | 0.271 | 13.33 (0.73 - 247.15)a | 0.081 |
Subpulmonary ventricular dysfunction at baseline | 0.56 (0.06 - 5.37) | 0.601 | 6.63 (0.73 - 60.22) | 0.093 |
Valvular dysfunction (> mild) | 1.25 (0.38 - 4.11) | 0.713 | 1.21 (0.42 - 3.47) | 0.724 |
NYHA class at baseline | 1.81 (0.65 - 5.09) | 0.259 | 2.25 (0.71 - 7.09) | 0.168 |
ACE-I/ARB use at baseline | 1.06 (0.29 - 3.89) | 0.935 | 1.15 (0.360 - 3.67) | 0.814 |
Diuretic use at baseline | 3.54 (1.04 - 12.04) | 0.044 | 15.62 (1.91 - 127.64) | 0.001 |
Beta blocker use at baseline | 1.07 (0.33 - 3.42) | 0.914 | 2.87 (0.94 - 8.66) | 0.055 |
Multiple Cancer diagnoses | 0.68 (0.13 - 3.54) | 0.640 | 2.0 (0.48 - 8.35) | 0.326 |
Cancer stage at diagnosis | 2.37 (1.32 - 4.25) | 0.004 | 0.80 (0.51 - 1.25) | 0.325 |
Any systemic cancer therapy use | 2.38 (0.68 - 8.36) | 0.160 | 1.03 (0.38 - 2.79) | 0.952 |
Platinum based compounds | 0.59 (0.11 - 3.00) | 0.521 | 0.89 (0.25 - 3.18) | 0.859 |
Kinase inhibitor | 2.44 (0.67 - 8.95) | 0.178 | 1.05. (0.30 - 3.65) | 0.939 |
Immune Checkpoint Inhibitor use | 11.36 (1.95 - 66.38) | 0.004 | 1.39 (0.24 - 8.17) | 0.713 |
Anthracycline use | 1.27 (0.29 - 5.49) | 0.753 | 0.63 (0.16 - 2.42) | 0.501 |
Mediastinal radiation therapy | 0.77 (0.19 - 3.16) | 0.711 | 1.47 (0.44 - 4.90) | 0.529 |