Table 1 Summary of patients with paclitaxel-induced cardiac ischemia
Case | Reported Year | Author | Cancer type | Age | Sex | Cardiovascular risk factora | Cycle of chemotherapy | Symptom | Onset | ECG changes | Coronary angiography | Treatment | Short term outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 1996 | Hekmat | Breast cancer | 67 | Female | Previously smoked | Second cycle | Chest pain | Fifteen hours after paclitaxel infusion | ST elevation in leads II, III and aVF | Not performed | Medical management only (Nitroglycerin) | Dead |
2 | 2005 | Schrader | Ovarian cancer | 58 | Female | None | First cycle | Chest pain, nausea | 20 min after paclitaxel infusion | ST elevation in leads II, III and avF | Not performed | Medical management only (Intraveneaous heparin) | Alive |
3 | 2009 | Gemici | Ovarian cancer | 51 | Female | Previous history of myocardiac infarction after paclitaxel administration | Second cycle | Chest pain, diaphoresis | Within minutes of paclitaxel administration | ST elevation in leads II, III, aVF, V3, V4, V5 and V6 | 80% stenosis of the left circumflex | Stent placement | Alive |
4 | 2009 | Londhey | Ovarian cancer | 48 | Female | None | Fifth cycle | Sudden circulatory collapse | Just after completion of paclitaxel infusion | ST elevation in lead V2 | Not performed | Medical management only (Intraveneaous heparin, oral aspirin) | Alive (Discharged after a week) |
5 | 2009 | Park | Ovarian cancer | 63 | Female | Hypertension | First cycle | Chest pain | Next day after paclitaxel administration | ST elevation in leads V2, V3, V4 and V5 | Filling defect in the left main coronary artery and 100% stenosis of the distal left anterior descending artery | Balloon angioplasty | Alive |
6 | 2012 | Shah | Ovarian cancer | 45 | Female | None | First cycle | Left-sided heaviness in the chest | 3 h after the completion of paclitaxel infusion | ST depression in leads V1, V2 and aVL | Not performed | Medical management only | Alive (Discharged from hospital after 10 days) |
7 | 2014 | Esber | Breast cancer | 47 | Female | None | Second cycle | Facial flushing, chest pain | Within 5 min of paclitaxel administration | ST elevation in leads V1, V2 and V3 | 95% stenosis of the proximal left anterior descending artery | Drug-elutinting stents placement | Dead |
8 | 2016 | Rawal | Esophageal cancer | 63 | Male | NA | NA | Chest Pain, breathlessness and hypotension | Just after completion of paclitaxel infusion | ST elevation in leads II, III and aVF | 100% stenosis of the proximal right coronary artery | Stent placement | Alive |
Current case | 2022 | Higami | Cervical cancer | 48 | Female | None | First cycle | Fatigue, diaphoresis | Just after completion of paclitaxel infusion | ST elevation in leads I, II, III, aVL, aVF, V4, V5 and V6 | Normal coronary angiography | Medical management only | Alive (but died of disease progression 10 months after diagnosis) |