Table 4 Time-to-first MACE event—Subgroup analysis

Past History of MACE

Yes

74

14.4 (1.9—112.3)

0.01

0.03

No

571

1.14 (0.4—3.8)

0.82

Sex

Male

431

4.2 (1.4—12.7)

0.01

0.13

Female

215

0.8 (0.1—8.1)

0.86

Age

 ≥ 75 years

192

5.21 (1.2—22.9)

0.03

0.23

 < 75 years

454

1.77 (0.6—13.3)

0.33

Ever smoker (current or former)

Yes

268

3.5 (1.0—12.5)

0.05

0.73

No

295

2.58 (0.6—10.6)

0.19

Disease extent at baseline

Locoregional disease (Stage II/III)

500

2.96 (1.1—7.9)

0.03

NA

Distant metastatic disease (Stage IV)

146

NA

NA

BRAF ± MEK inhibitor use

Yes

72

1.2 (0.1—19.0)

0.9

0.47

No

573

3.46 (1.3—8.9)

0.01