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Table 1 Main characteristics of the analyzed studies

From: Cancer incidence and mortality in patients diagnosed with heart failure: results from an updated systematic review and meta-analysis

Study

Design

Total N of Patients

Follow-Up Time

Exclusion Criteria

HF Patients’ Age (years)

No HF Patients’ Age (years)

Male Sex

HF No HF

HF Definition

Hasin et al., 2013 [8]

Case-control and prospective cohort study

1.922 (961/961) case-control; 1.192 (596/596) cohort.

7.7 ± 6.4 years

Prior cancer

73,0 ± 14,0

73,0 ± 14,0

47%

47%

Medical chart review (Framingham criteria)

Banke et al., 2016 [9]

Cohort study

4.968,582 (9304/4.959.275)

4.5 ± 2.3 years

Prior cancer

51,6 ± 7,1

N.A.

72.6%

Clinical evaluation and echocardiography

Hasin et al., 2016 [10]

Prospective cohort study

1.081 (228/853)

4.9 ± 3 years

Prior cancer, nonmelanoma skin cancer

62,0 ± 15,0

72,0 ± 14,0

46%

63%

Medical chart review (Framingham criteria)

Selvaraj et al., 2018 [11]

Prospective cohort study (post-hoc analysis of RCT)

28.341 (1.420/26.921)

19.9 years

Prior cancer

61,0 ± 9,0

55,0 ± 1,0

100%

Self report validated by Framingham criteria

Schwartz et al., 2020 [12]

Retrospective cohort Study

1.004.759 (167.633/837.126)

Mean 3.0 years for HF group/6.8 yeas for control group

Prior cancer

70,9 ± 13,3

70,9 ± 13,3

55%

55%

ICD-10 codes

Kwak et al., 2020 [13]

Retrospective cohort study

770.646 (128.441/642.205)

4.06 years

Prior cancer

67,1 ± 12,4

67,1 ± 12,4

51.9%

51.9%

ICD-10 code with at least one hospital admission attributed to HF diagnosis

Roderburg et al., 2021 [14]

Retrospective cohort study

200.248 (100.124/100.124)

10 years

Prior cancer

72,6 ± 12,2

72,6 ± 12,2

46%

46%

ICD-10 code and drug prescriptions

Leedy et al., 2021 [15]

Post-hoc analysis of a prospective cohort study

146.817 (3.272/104.020)

8.4 years

Prior cancer, no follow-up data, self-reported HF

63,1 ± 6,7

N.A.

None

Clinical review of hospitalization records with primary diagnosis of HF event

Bertero et al., 2021 [16]

Retrospective cohort study

208.040 (104.020/104.020)

Mean 5.6 years for HF group/5.3 years for controls

Prior cancer; age < 50 years

76,0 ± 10,0

76,0 ± 10,0

46.8%

46.8%

Health Care records on drug prescriptions, outpatients visit reports, health care cost-related fee waivers, death certificates.