Table 1 Baseline characteristics
N | RHI | ||||
|---|---|---|---|---|---|
All | Low RHI (< 1.67) | Borderline RHI (≥ 1.67 and < 2.1) | Normal RHI (≥ 2.1) | P-value | |
N = 30 | N = 10 | N = 14 | N = 6 | ||
Age, yrs | 43.5 ± 9.8 | 42.6 ± 9.5 | 44.4 ± 11.6 | 43.0 ± 6.4 | 0.908 |
Male/Female, n (%) | 17/13 (57/43) | 8/2 (80/20) | 6/8 (43/57) | 3/3 (50/50) | 0.181 |
Height, cm | 166.3 ± 8.7 | 168.1 ± 9.0 | 163.6 ± 8.5 | 170.0 ± 7.8 | 0.252 |
Weight, kg | 67.5 ± 13.6 | 69.9 ± 13.2 | 63.3 ± 12.4 | 73.2 ± 15.9 | 0.265 |
BMI, kg/m2 | 24.3 ± 3.7 | 24.7 ± 4.0 | 23.5 ± 2.8 | 25.4 ± 4.9 | 0.535 |
Systolic BP, mmHg | 122.6 ± 21.9 | 122.4 ± 17.1 | 128.1 ± 24.2 | 110.0 ± 21.0 | 0.245 |
Diastolic BP, mmHg | 69.4 ± 15.6 | 74.0 ± 11.0 | 70.6 ± 15.5 | 58.7 ± 19.4 | 0.149 |
Current smoker, n (%) | 7 (23.3) | 5 (50.0) | 2 (14.3) | 0 (0) | 0.151 |
Former smoker, n (%) | 6 (20.0) | 1 (10.0) | 3 (21.4) | 2 (33.3) | 0.151 |
Hypertension, n (%) | 6 (20.0) | 2 (20.0) | 3 (21.4) | 1 (16.7) | 0.971 |
Dyslipidemia, n (%) | 16 (53.3) | 5 (50.0) | 8 (57.1) | 3 (50.0) | 0.926 |
Diabetes mellitus, n (%) | 3 (10.0) | 2 (20.0) | 1 (7.1) | 0 (0) | 0.386 |
MMR, n (%) | 9 (30.0%) | 2 (20.0%) | 4 (28.6%) | 3 (50.0%) | 0.683 |
DMR, n (%) | 18 (60.0%) | 7 (70.0%) | 8 (57.1%) | 3 (50.0%) | 0.683 |
Current medication | |||||
TKI Imatinib | 5 (16.7) | 1 (10.0) | 2 (14.3) | 2 (33.3) | 0.151 |
Nilotinib | 12 (40.0) | 3 (30.0) | 8 (57.1) | 1 (16.7) | |
Dasatinib | 4 (13.3) | 1 (10.0) | 2 (14.3) | 1 (16.7) | |
Bosutinib | 5 (16.7) | 2 (20.0) | 2 (14.3) | 1 (16.7) | |
Ponatinib | 4 (13.3) | 3 (30.0) | 0 (0) | 1 (16.7) | |
TKI duration, days | 1466 [980–2256] | 1643 [1213–2160] | 1352 [925–2128] | 1354 [1074–2370] | 0.830 |
Statin, n (%) | 12 (40.0) | 3 (30.0) | 7 (50.0) | 2 (33.0) | 0.574 |
ACE-I/ARB, n (%) | 5 (16.7) | 1 (10.0) | 3 (21.4) | 1 (16.7) | 0.760 |
CCB, n (%) | 5 (16.7) | 1 (10.0) | 3 (21.4) | 1 (16.7) | 0.760 |
Xanthine oxidase inhibitor, n (%) | 3 (10.0) | 2 (20.0) | 0 (0) | 1 (16.7) | 0.227 |
Laboratory data | |||||
WBC, × 103/µL | 6.5 ± 1.9 | 6.9 ± 1.9 | 6.7 ± 2.1 | 5.4 ± 1.5 | 0.277 |
Hemoglobin, g/dL | 13.6 ± 1.7 | 14.6 ± 1.7 | 13.3 ± 1.9 | 12.8 ± 1.5 | 0.082 |
Serum creatinine, mg/dL | 0.78 ± 0.25 | 0.84 ± 0.17 | 0.77 ± 0.32 | 0.72 ± 0.18 | 0.642 |
Serum uric acid, mg/dL | 5.0 ± 1.2 | 5.7 ± 0.9 | 4.8 ± 1.2 | 4.5 ± 1.5 | 0.077 |
Triglycerides, mg/dL | 83 [56–116] | 74 [56–163] | 72 [52–101] | 98 [78–169] | 0.243 |
HDL-C, mg/dL | 61 ± 16 | 64 ± 20 | 62 ± 14 | 53 ± 15 | 0.450 |
LDL-C, mg/dL | 110 ± 28 | 104 ± 29 | 122 ± 22 | 92 ± 32 | 0.068 |
HbA1c, % | 5.6 ± 0.58 | 5.8 ± 0.86 | 5.5 ± 0.35 | 5.6 ± 0.28 | 0.362 |