Fig. 5

Myocarditis classification with and without supplemental immunohistochemistry (IHC) staining. Heatmaps of standard myocarditis classification criteria and selected variables from patients with immune checkpoint inhibitor-associated myocarditis. A Myocarditis classification without IHC and B potential reclassification with CD68 positive IHC. Each column represents characteristics from one patient (n = 26). Blue boxes represent negative/normal data, red boxes represent positive/abnormal data, and gray boxes represent studies not performed. *For steroids, red boxes represent high dose steroids that are defined as the equivalent of intravenous methylprednisolone of 1 gm or higher, blue boxes represent other steroids which are defined as a less than 1 gm, and gray boxes represent no steroids given. CMR = cardiac magnetic resonance imaging; CRP = C-reactive protein; CV = cardiovascular; ECG = electrocardiogram; LGE = late gadolinium enhancement; NT-proBNP = N-terminal pro-brain natriuretic peptide