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Table 1 Patient characteristics – cardiovascular

From: Clinicopathological classification of immune checkpoint inhibitor-associated myocarditis: possible refinement by measuring macrophage abundance

 

All

(n = 26)

Possible (n = 6)

Probable (n = 9)

Definite (n = 11)

P

P (Pos vs Pro)

P (Pos vs Def)

P (Pro vs Def)

Age at clinical diagnosis (yr)

64 ± 12

65 ± 8

63 ± 9

65 ± 16

0.904

   

Sex

 Female

10 (38)

1 (17)

4 (44)

5 (45)

 

0.999

0.333

0.637

 Male

16 (62)

5 (83)

5 (56)

6 (55)

    

Race

 Black or African American

3 (12)

0

2 (22)

1 (9)

 

0.486

0.999

0.566

 White, non-Hispanic

23 (88)

6 (100)

7 (78)

10 (91)

    

Cardiovascular Risk Factors

 History of smoking

17 (65)

6 (100)

2 (22)

9 (82)

 

0.0070

0.515

0.0216

 Hypertension

19 (73)

4 (67)

8 (89)

7 (64)

 

0.525

0.999

0.319

 Diabetes mellitus

6 (23)

1 (17)

3 (33)

2 (18)

 

0.604

0.999

0.617

Coronary Artery Disease

12 (46)

3 (50)

2 (22)

7 (64)

 

0.329

0.645

0.092

Prior Cardiomyopathy (any)

8 (31)

3 (50)

1 (11)

4 (36)

 

0.559

0.999

0.282

Stroke

2 (8)

0

0

2 (18)

 

0.999

0.515

0.479

Cardiovascular Medications

 Statin

11 (42)

3 (50)

3 (33)

5 (45)

 

0.622

0.999

0.670

 Aspirin

15 (58)

4 (67)

4 (44)

7 (64)

 

0.608

0.999

0.653

 Beta-blockers

13 (50)

5 (83)

1 (11)

7 (64)

 

0.0110

0.600

0.0281

 RAAS inhibitors

18 (69)

6 (100)

5 (56)

7 (64)

 

0.103

0.237

0.999

  1. Values are expressed as mean ± standard deviation or n (%). Fisher’s exact test was used when comparing categorical variables and Student’s t-test or analysis of variance when comparing continuous variables. P values < 0.05 were considered significant. Possible, Probable, and Definite are based on the proposed reclassified myocarditis patient cohorts
  2. RAAS   Renin–angiotensin–aldosterone system, yr years