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Table 1 Baseline Clinical Characteristics Based on Cardiac Events

From: Cardiac and inflammatory biomarker differences in adverse cardiac events after chimeric antigen receptor T-Cell therapy: an exploratory studyAuthors and Affiliation

Variables

Cardiac Events

(N = 11)

No Cardiac Events (N = 79)

p value

Age at CAR-T

77.0

[69.5;79.0]

66.0

[56.5;73.0]

0.002

Gender

  

0.241

 Male

9 (81.8%)

46 (58.2%)

 

 Female

2 (18.2%)

33 (41.8%)

 

Ethnicity

  

0.747

 White

11 (100.0%)

75 (94.9%)

 

 Black

0 (0.0%)

3 (3.8%)

 

 Other

0 (0.0%)

1 (1.3%)

 

Cancer Type

  

0.518

 DLBCL

5 (45.5%)

49 (62.0%)

 

 TFL

1 (9.1%)

7 (8.9%)

 

 B-ALL

0 (0.0%)

3 (3.8%)

 

 MCL

5 (45.5%)

20 (25.3%)

 

Type of CAR-T

  

0.514

 Yescarta

4 (36.4%)

36 (45.6%)

 

 Kymriah

2 (18.2%)

19 (24.1%)

 

 Tecartus

5 (45.5%)

20 (25.3%)

 

 Breyanzi

0 (0.0%)

4 (5.1%)

 

Heart Rate (bpm)

79.7 ± 9.7

86.4 ± 16.2

0.186

Systolic BP (mmHg)

122.9 ± 18.9

116.0 ± 15.7

0.185

Diastolic BP (mmHg)

71.2 ± 12.9

71.7 ± 8.4

0.905

Creatinine (mg/dL)

0.9 [ 0.8; 1.1]

0.7 [ 0.6; 0.8]

0.007

CRP (mg/dL)

2.6 [ 0.7; 5.9]

2.2 [ 0.8; 5.8]

0.935

Hemoglobin (g/dL)

9.5 [ 7.9;10.1]

9.3 [ 8.2;10.8]

0.596

Platelet count (in 103/uL)

94.0 [83.5;124.0]

143.0 [87.0;179.0]

0.148

Troponin I (ng/mL)

0.013 [0.010;0.036]

0.010 [0.010;0.011]

0.055

BNP (pg/mL)

59.5 [25.7;113.0]

51.0 [18.0;145.5]

0.775

LV Ejection Fraction (%)

55.0 [55.0;60.0]

60.0 [55.0;60.0]

0.502

MV E Velocity (cm/s)

70.9 ± 15.2

67.2 ± 18.2

0.527

MV A Velocity (cm/s)

75.0 [68.5;86.5]

74.0 [63.5;87.5]

0.815

MV E/A Ratio

0.9 [ 0.8; 1.1]

0.9 [ 0.7; 1.1]

0.494

Average E/e’

10.8 [ 8.9;15.9]

9.2 [ 7.0;11.4]

0.082

LV Diameter in Diastole (cm)

5.1 ± 0.5

4.7 ± 0.6

0.054

LV Diameter in Systole (cm)

3.4 ± 0.5

3.1 ± 0.5

0.12

IV Septum Thickness (cm)

1.0 ± 0.1

0.9 ± 0.2

0.123

Posterior Wall Thickness (cm)

1.0 ± 0.2

1.0 ± 0.2

0.169

Aortic Root Diameter (cm)

3.1 ± 0.5

2.9 ± 0.4

0.283

Indexed LA Volume (mL/m2)

23.9 [19.5;25.8]

16.9 [13.8;23.4]

0.042

Global Longitudinal Strain (%)

-17.0 ± 2.4

-17.7 ± 3.5

0.647

  1. Data presented as Median [ Interquartile range], mean ± standard deviation, or number (percentage) depending on the type and normality of data
  2. Abbreviations: CAR-T: chimeric antigen-receptor T cell, LBCL: large B- cell lymphoma, FL: follicular lymphoma, B-ALL: B-cell acute lymphoid leukemia, MCL: mantle cell lymphoma, MV: mitral valve, LV: left ventricle, IV: interventricular, LA: left atrium
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Cardio-Oncology

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