Fig. 2
From: Mechanisms of trastuzumab induced cardiotoxicity – is exercise a potential treatment?
Trastuzumab treatment leads to apoptotic signalling in cardiomyocytes.
The anti-ErbB2 antibody trastuzumab causes mitochondrial permeability transition pore (MPTP) opening and increased reactive oxygen species (ROS) production, both contributing to impaired mitochondrial function [30]. Cytochrome-c release from the mitochondrial intermembrane space promotes caspase activation and apoptotic signalling via BAX/BAK