Table 2 T1 value changes in RT-induced MCT studies using MRI (no dose-dependency was reported)

Van Der Velde et al., [50]

80

HL & NHL

-

Significant increase of native T1 values compared to healthy control at 20 years post-RT

(980±33 ms vs 964±25 ms, p=0.01)

-

Traber et al., [51]

10

Thoracis malignancies

-

-

Normal range: (baseline (966±39 ms),

half-time RT (956±14 ms),

and after RT (968±72 ms))

Takagi et al., [57]

24

Esophagus

-

In the basal septum (highly radiated area, 43±4 Gy), native T1 values were higher at 0.5 year (1257±35 ms, P<0.01) and

1.5 year (1238±56 ms, P< 0.024) compared to the baseline (1183±46 ms)

At the apical lateral wall (nonradiated area 3±4 Gy), no significant T1 differences were found at different time points

Speers et al., [47]

51

Breast

End of the treatment

(−20 ms, p=0.022)

and three months

post-treatment

(−23 ms, P< 0.001)

-

-

Tahir et al., [55]

66

Breast

-

In epirubicin-chemotherapy-based followed by RT group:

baseline: 1244±29 ms,

therapy completion: 1293±34 ms, P<0.001)

In epirubicin-chemotherapy-based followed

by RT group: changes returned to baseline

at 13±2 months (1250±26 ms)

-

-

In left -sided RT only group: constant

(baseline: 1237±29 ms,

at therapy completion: 1237±42 ms,

and 13±2 months: 1239±39 ms)

Ricco et al., [62]

28

Chest tumor

-

-

Mean T1: 1009 ms (range 933–1117 ms)

with no dose-dependency at 46.4 months post-RT (p=0.054)

Vallabhaneni et al.,[54]

11

Lung, breast, lymphoma

-

-

No significant %T1 changes in

patients with higher radiation (-1.3±3.7%) or patients with minimal radiation (-3.7±2.0%) at 6 months post-RT

de Groot et al., [63]

40

Esophagus

-

-

No differences between neoadjuvant chemoradiotherapy and control

(959.2±34.7 ms vs 949.9±28.4 ms, p=0.4) at 67.6 months