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Table 5 Supine ExeCMR + CPET Parameters

From: Simultaneous exercise stress cardiac magnetic resonance and cardiopulmonary exercise testing to elucidate the Fick components of aerobic exercise capacity: a feasibility and reproducibility study and pilot study in hematologic cancer survivors

Variable

Healthy Controls

(n = 6)

Patients with Cancer

(n = 6)

P-value

Rest Parameters

   

LV Mass Index, grams/m2

69.7 [63.4–75.7]

64.1 [59.4–71.8]

0.485

LVEDV Index, mL/m2

75.3 [71.0-93.2]

84.0 [74.5–86.6]

0.818

LVESV Index, mL/m2

29.6 [23.5–38.2]

40.0 [32.6–44.0]

0.041

SVI, mL/m2/beat

47.6 [45.4–55.0]

40.5 [38.7–46.3]

0.041

LVEF, %

60.5 [58.8–67.3]

51.0 [47.8–55.8]

0.026

Cardiac Index, L·min− 1/m2

2.87 [2.51–3.03]

3.09 [2.80–3.29]

0.180

 HR, bpm

56 [52–62]

70 [63–85]

0.009

MAP, mmHg

89 [84–102]

87 [82–91]

0.394

VO2, L·min− 1/m2

0.133 [0.118–0.158]

0.156 [0.136–0.204]

0.132

VO2, mL·kg− 1·min− 1

3.4 [2.9–3.8]

3.6 [3.2–4.8]

0.310

RER

0.85 [0.77–0.92]

0.82 [0.74–0.95]

0.699

a-vO2 difference, mLO2/dL

5.3 [4.1–5.4]

4.9 [4.7–6.8]

0.818

VE, L·min− 1

7.1 [5.9–8.4]

9.3 [7.6–12.9]

0.026

RR, breaths/min

11 [11-14]

16 [14-21]

0.015

VT, L

0.61 [0.54–0.63]

0.57 [0.43–0.74]

1.000

Peak Exercise Parameters

   

Power output, Watts

147 [96–165]

95 [61–105]

0.065

LVEDV Index, mL/m2

75.9 [72.1–85.1]

72.8 [65.3–81.4]

0.589

LVESV Index, mL/m2

20.5 [13.5–22.3]

29.3 [19.7–36.4]

0.132

SV Index, mL/m2

60.2 [53.7–64.6]

42.4 [36.8–50.3]

0.026

LVEF, %

76.5 [71.3–81.5]

59.5 [53.3–72.8]

0.015

Cardiac Index, L·min− 1/m2

7.4 [7.0-8.8]

5.0 [4.7–6.3]

0.004

 HR, bpm

129 [124–136]

124 [105–140]

0.485

MAP, mmHg

117 [100–127]

117 [102–133]

0.931

VO2, L·min− 1/m2

1.07 [0.74–1.25]

0.73 [0.58-1.00]

0.065

VO2, mL·kg− 1·min− 1

26.0 [19.7–29.5]

17.1 [13.5–23.5]

0.026

RER

1.05 [1.01–1.09]

0.98 [0.91–1.26]

0.485

a-vO2 difference, mLO2/dL

13.6 [10.9–15.4]

14.4 [11.8–16.9]

0.589

VE, L·min− 1

61.9 [40.3–80.0]

53.2 [34.9–61.7]

0.310

RR, breaths/min

31 [26-35]

32 [27-37]

0.818

VT, L

2.00 [1.73–2.28]

1.78 [1.18–2.03]

0.240

RPE (6–20)

16 [15-17]

17 [16-18]

0.589

  1. Data are presented as median [interquartile range]. P-values for difference between patients with cancer and healthy controls.
  2. Abbreviations: a-vO2 = arteriovenous oxygen; CMR + CPET = exercise stress cardiac magnetic resonance coupled with cardiopulmonary exercise testing; HR = heart rate; LV = left-ventricle; LVEDV = left-ventricular end-diastolic volume; LVEF = left-ventricular ejection fraction; LVESV = left-ventricular end-systolic volume; MAP = mean arterial pressure; RER = respiratory exchange ratio; RR = respiratory rate; SV = stroke volume; VE = minute ventilation; VO2 = oxygen consumption; VT=tidal volume.