Table 5 Sensitivity, hazard ratio for association between positive test and mortality rate, and hazard ratio for mortality among those not tested compared to those tested, among patients with immune checkpoint inhibitor myocarditis, using cox bivariable regression
Diagnostic test | n = (34) | Sensitivity | HR for mortality rate (95% CI) | p-value | HR for mortality (tested vs not tested) (95% CI) | p-value |
|---|---|---|---|---|---|---|
5th gen Troponin T* | 33 | 97% | 6.25 (1.54 to 25.27) | 0.01 | ||
Anti-striated antibody | 7 | 57.14% | ||||
QRS duration > 120 ms | 34 | 47% | 5.13 (1.06 to 24.78) | 0.04 | ||
Sokolow-Lyon Index < 13 mV | 33 | 39.39% | 7.42 (1.53 to 35.94) | 0.01 | ||
2-D echocardiogram | ||||||
LVEF < 50% | 29 | 34.48% | 0.22 (0.03 to 1.77) | 0.15 | 1.28 (0.16 to 10.22) | 0.82 |
RWMA | 33 | 33.33% | 0.21 (0.03 to 1.70) | 0.15 | ||
CMR | 16.15 (2.01 to 129.75) | < 0.01 | ||||
Diagnostic certainty | n = (%) | Mortality rate (deaths per 100 days) | HR for mortality (95% CI) | p-value | ||
Definite myocarditis | 14 (41.18%) | 0.04 (0.01 to 0.29) | 1.00 | |||
Probable myocarditis | 7 (20.59%) | 0.09 (0.01 to 0.61) | 2.10 (0.13 to 33.58) | 0.13 | ||
Possible myocarditis | 13 (38.24%) | 0.47 (0.22 to 0.98) | 10.67 (1.31 to 87.09) | 0.03 | ||
Test for departure from linear trend with increasing diagnostic certainty: LR χ2 = 0.16, p = 0.69, 1 d.f | ||||||