Table 6 Association between strain imaging, outcome variables and predictor variables among patients with immune checkpoint inhibitor myocarditis
Level of longitudinal strain | ||||||||
|---|---|---|---|---|---|---|---|---|
Sensitivity (> -18%) for ICI myocarditis | Global Strain | Apical Strain | Mid strain | Basal strain | ||||
83.33% | 58.33% | 91.67% | 87.5% | |||||
Comparison | ||||||||
(Sign rank null hypothesis) | Median | P = | Median | P = | Median | P = | Median | P = |
Strain = -18% | -15.56% | < 0.001 | -16.79% | 0.188 | -15.07% | < 0.001 | -14.78% | 0.001 |
Strain = apical strain | 0.007 | –- | 0.010 | 0.043 | ||||
Outcome variables | ||||||||
(Cox regression) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | ||||
CHB | 0.864 (0.67 to 1.11) | 0.250 | 0.902 (0.75 to 1.09) | 0.283 | 0.895 (0.69 to 1.16) | 0.393 | 0.936 (0.78 to 1.13) | 0.491 |
Death | 1.027 (0.80 to 1.32) | 0.837 | 1.016 (0.84 to 1.23) | 0.874 | 0.969 (0.76 to 1.23) | 0.798 | 0.979 (0.81 to 1.19) | 0.827 |
Predictor variables | Correlation | Correlation | Correlation | Correlation | ||||
Troponin T | Rho = -0.432 | 0.040 | Rho = -0.145 | 0.508 | Rho = -0.483 | 0.020 | Rho = -0.524 | 0.010 |
PR interval | Rho = -0.401 | 0.080 | Rho = -0.199 | 0.401 | Rho = -0.381 | 0.097 | r = -0.322 * | 0.167 |
QRS duration | Rho = -0.056 | 0.796 | Rho = 0.180 | 0.399 | Rho = -0.185 | 0.388 | Rho = -0.085 | 0.695 |
Sokolow Lyon Index | r = 0.4402 * | 0.036 | Rho = 0.102 | 0.644 | Rho = -0.011 | 0.962 | r = 0.630 * | 0.001 |