Table 7 Severity classification for immune checkpoint inhibitor myocarditis based on risk of developing CHB
Predictor variables | Mild All of: | Moderate Any 1 of: | Severe | |
|---|---|---|---|---|
Troponin T | ≤ 1000 ng/dL | TnT > 1000 ng/dL | - | |
ECG* | ||||
PR interval | ≤ 200 ms | > 200 ms | - | |
QRS duration | ≤ 120 ms | > 120 ms | - | |
Sokolow Lyon Index | > 14 mV | ≤ 14 mV | - | |
CHB | Not present | Not present | Present | |
Mortality rate (100 person-days) (95% CI) | 0 | 0.126 (0.05 to 0.33) | 0.741 (0.31 to 1.78) | |
Proportion (%) | 7 (20.59%) | 20 (58.82%) | 7 (20.59%) | |
Cox HR for linear association between severity and mortality rate | HR 6.273 (2.127 to 18.506), p < 0.001 | |||