Cardiac electrical abnormalities in childhood acute lymphoblastic leukemia survivors: a systematic review

Bertrand, Émilie; Caru, Maxime; Harvey, Audrey; Dodin, Philippe; Jacquemet, Vincent; Curnier, Daniel

doi:10.1186/s40959-023-00188-9

Cardio-Oncology

Table 4 Total prevalence of cardiac electrical abnormalities

From: Cardiac electrical abnormalities in childhood acute lymphoblastic leukemia survivors: a systematic review

Abnormalities	Bertrand et al. (2021) [50]	Brouwer et al. (2007) [51]	Halazun et al. (1974) [52]	Hau et al. (2019) [53]	Lipshultz et al. (1991) [3]	Pihkala et al. (1994) [49]	Velensek Prestor et al. (2000) [17]	Ram-meloo et al. (2000) [54]	Shim-momura et al. (2011) [55]	Steinherz et al. (1995) [48]	Turner-Gomes et al. (1996) [56]	Total
Author (date)	Bertrand et al. (2021) [50]	Brouwer et al. (2007) [51]	Halazun et al. (1974) [52]	Hau et al. (2019) [53]	Lipshultz et al. (1991) [3]	Pihkala et al. (1994) [49]	Velensek Prestor et al. (2000) [17]	Ram-meloo et al. (2000) [54]	Shim-momura et al. (2011) [55]	Steinherz et al. (1995) [48]	Turner-Gomes et al. (1996) [56]	Total
Heart rate	147										0	147
Participants	216										19	235
Prevalence	68%										0%	63%
Tachycardia					8					1		9
Participants					96					2		98
Prevalence					8%					50%		9%
Bradycardia							4					4
Participants							46					46
Prevalence							9%					9%
Prolonged QT		0					2	0				2
Participants		23					46	90				159
Prevalence		0%					4%	0%				1%
ST segment			2			0	10		1			13
Participants			172			9	45		61			287
Prevalence			1%			0%	22%		2%			5%
T waves		7	11					1				19
Participants		23	172					90				285
Prevalence		30%	6%					1%				7%
Pathological Q waves		0	2									2
Participants		23	172									195
Prevalence		0%	1%									1%
No sinus rhythm		0						3				3
Participants		23						89				112
Prevalence		0%						3%				3%
Ventricular tachycardia					4		2	0				6
Participants					89		46	89				224
Prevalence					4%		4%	0%				3%
Ventricular ectopy					12					1		13
Participants					96					2		98
Prevalence					13%					50%		13%
Atrial ectopy					3							3
Participants					96							96
Prevalence					3%							3%
Arrhythmias				27								27
Participants				511								511
Prevalence				5%								5%
Ventricular arrhythmias										2		2
Participants										2		2
Prevalence										100%		100%
Ventricular premature contractions		3					3	3	2	1		12
Participants		23					44	89	59	2		217
Prevalence		13%					7%	4%	3%	50%		6%
Prolonged QRS interval								1				1
Participants								90				90
Prevalence								1%				1%
Premature atrial contractions								4				4
Participants								90				90
Prevalence								4%				4%
Anormal AV conduction		0										0
Participants		23										23
Prevalence		0%										0%
Right bundle branch block							1					1
Participants							46					46
Prevalence							2%					2%
Abnormal P waves			17									17
Participants			172									172
Prevalence			10%									10%
Second-degree AV block type I								3				3
Participants								89				89
Prevalence								3%				3%
Low QRS voltage			14			3		1				18
Participants			172			8		90				270
Prevalence			8%			38%		1%				7%
Abnormal QRS axis			9									9
Participants			172									172
Prevalence			5%									5%
Low T voltage			15									15
Participants			172									172
Prevalence			9%									9%
Abnormal T axis			11									11
Participants			172									172
Prevalence			6%									6%
Total	147	10	64	27	27	3	12	16	3	5	0	341
Participants	216	138	1204	511	377	17	228	806	120	8	19	3861
Prevalence	68%	7%	5%	5%	7%	18%	5%	2%	3%	63%	0%	9%

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