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Table 3 Cox proportional hazards regression for all-cause mortality

From: Sodium-glucose co-transporter-2 inhibitors in patients treated with immune checkpoint inhibitors

 

Hazard Ratio

95.0% CI

P value

Lower

Upper

 

SGLT-2 (yes/no)

0.300

0.104

0.865

0.026

Age

1.016

0.983

1.050

0.338

Gender

0.494

0.241

1.014

0.054

Cancer Types

   

0.030

 NSCLC

0.583

0.214

1.588

0.291

 Melanoma

0.401

0.165

0.979

0.045

 Renal Cell Carcinoma

2.716

1.024

7.202

0.045

 Hepatocellular Carcinoma

3.515

0.617

20.044

0.157

 Breast

1.092

0.264

4.520

0.903

 Cervical Squamous

1.180

0.355

3.925

0.787

Chemotherapy/Biological_plus_ICIs

   

0.115

 Chemo_plus_ICIs

0.770

0.301

1.967

0.584

 Biological_plus_ICIs

0.247

0.066

0.923

0.038

Cancer Stage

   

0.175

 Stage at immuno Start(1)

0.450

0.031

6.517

0.559

 Stage at immuno Start(2)

1.565

0.152

16.118

0.706

Hypertension

1.112

0.543

2.275

0.772

Ischemic Heart Disease-Baseline

0.713

0.308

1.648

0.429

Obesity

1.717

0.407

7.238

0.461

Hyperlipidemia

0.537

0.257

1.122

0.098

Chronic Kidney Disease

.768

.244

2.423

0.653

Statin

1.720

.814

3.634

0.155

RAASi treatment

.898

.445

1.813

0.765

  1. *Stage 2 for reference