Table 3 GRADE evidence profile
Certainty assessment | ||||||
|---|---|---|---|---|---|---|
Participants (studies) Follow-up | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | Overall certainty of evidence |
VO2 peak, ml/kg/min Change | ||||||
777 (8 RCTs) | not serious | very seriousa | not serious | not serious | none | ⨁⨁◯◯ Low |
Echocardiographic outcomes—Left Ventricular Ejection fraction (%) change | ||||||
403 (8 RCTs) | not serious | not serious | not serious | very seriousb | none | ⨁⨁◯◯ Low |
Echocardiographic outcomes—Global Longitudinal strain (%) Change | ||||||
332 (6 RCTs) | not serious | seriousc | not serious | very seriousb | none | ⨁◯◯◯ Very low |
Echocardiographic outcomes—Stroke volume (ml) change | ||||||
260 (5 RCTs) | not serious | very seriousa | not serious | extremely seriousb | none | ⨁◯◯◯ Very low |
Echocardiographic outcomes—Left Ventricular end-diastolic volume (ml) change | ||||||
166 (4 RCTs) | not serious | not serious | not serious | extremely seriousb | none | ⨁◯◯◯ Very low |
Echocardiographic outcomes—Left Ventricular end-systolic volume (ml) change | ||||||
166 (4 RCTs) | not serious | not serious | not serious | very seriousb | none | ⨁⨁◯◯ Low |
Echocardiographic outcomes—E/A ratio change | ||||||
295 (5 RCTs) | not serious | not serious | not serious | seriousd | none | ⨁⨁⨁◯ Moderate |
Echocardiographic outcomes—Cardiac output (L/min) change | ||||||
239 (4 RCTs) | not serious | very seriousa | not serious | seriousb | none | ⨁◯◯◯ Very low |
Adverse events—Any adverse event | ||||||
227 (6 RCTs) | not serious | seriousc | not serious | very seriouse | none | ⨁◯◯◯ Very low |
Adverse events—Any serious advere event | ||||||
249 (7 RCTs) | not serious | not serious | not serious | very seriouse | none | ⨁⨁◯◯ Low |
Adverse events—Any advere event leading to withdrawal | ||||||
295 (7 RCTs) | not serious | not serious | not serious | very seriouse | none | ⨁⨁◯◯ Low |
Adverse events—All-Cause Mortality | ||||||
295 (7 RCTs) | not serious | not serious | not serious | very seriouse | none | ⨁⨁◯◯ Low |
RER Change | ||||||
173 (4 RCTs) | not serious | not serious | not serious | very seriousf | none | ⨁⨁◯◯ Low |
Resting Heart rate (BPM) Change | ||||||
215 (5 RCTs) | not serious | not serious | not serious | very seriousb | none | ⨁⨁◯◯ Low |
Peak Heart rate (BPM) Change | ||||||
258 (6 RCTs) | not serious | not serious | not serious | very seriousb | none | ⨁⨁◯◯ Low |
Resting Systolic blood pressure (mmHg) Change | ||||||
113 (4 RCTs) | not serious | not serious | not serious | very seriousb | none | ⨁⨁◯◯ Low |
Resting Diastolic blood pressure (mmHg) Change | ||||||
113 (4 RCTs) | not serious | not serious | not serious | very seriousb | none | ⨁⨁◯◯ Low |