World Health Organization (WHO). World Health Organization Statistical Information System (WHOSIS) (updated 17 November 2015) (http://www.who.int/gho/en/), 2010.
McMillan TJ, Bennett MR, Bridges BA, Darby SC, Hendry J, Jones B, et al. Circulatory disease risk. Report of the independent Advisory Group on Ionising Radiation. Holborn Gate, 330 High Holborn, London: Health Protection Agency; 2010. p. 1–116.
Wilson PWF, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97(18):1837–47.
Clifton VL, Stark MJ, Osei-Kumah A, Hodyl NA. Review: The feto-placental unit, pregnancy pathology and impact on long term maternal health. Placenta 2012;33 Suppl:S37-41 doi:10.1016/j.placenta.2011.11.005 [published Online First: Epub Date]|.
Dior UP, Hochner H, Friedlander Y, Calderon-Margalit R, Jaffe D, Burger A, et al. Association between number of children and mortality of mothers: results of a 37-year follow-up study. Ann Epidemiol. 2013;23(1):13–8. doi:10.1016/j.annepidem.2012.10.005. [published Online First: Epub Date]|.
United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). UNSCEAR 2006 Report. Annex A. Epidemiological Studies of Radiation and Cancer. New York: United Nations; 2008. p. 13–322.
Google Scholar
Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation. National Research Council. Health Risks from Exposure to Low Levels of Ionizing Radiation: BEIR VII - Phase 2. Washington, DC: National Academy Press; 2006. p. 1–406.
Ozasa K, Shimizu Y, Suyama A, Kasagi F, Soda M, Grant EJ, et al. Studies of the mortality of atomic bomb survivors, report 14, 1950–2003: an overview of cancer and noncancer diseases. Radiat Res. 2012;177(3):229–43. doi:10.1667/RR2629.1 [published Online First: Epub Date].
Preston DL, Ron E, Tokuoka S, Funamoto S, Nishi N, Soda M, et al. Solid cancer incidence in atomic bomb survivors: 1958–1998. Radiat Res. 2007;168(1):1–64. doi:10.1667/RR0763.1 [published Online First: Epub Date].
Adams MJ, Hardenbergh PH, Constine LS, Lipshultz SE. Radiation-associated cardiovascular disease. Crit Rev Oncol Hematol. 2003;45(1):55–75 [published Online First: Epub Date].
Little MP, Tawn EJ, Tzoulaki I, Wakeford R, Hildebrandt G, Paris F, et al. A systematic review of epidemiological associations between low and moderate doses of ionizing radiation and late cardiovascular effects, and their possible mechanisms. Radiat Res. 2008;169(1):99–109. doi:10.1667/RR1070.1 [published Online First: Epub Date].
Little MP, Tawn EJ, Tzoulaki I, Wakeford R, Hildebrandt G, Paris F, et al. Review and meta-analysis of epidemiological associations between low/moderate doses of ionizing radiation and circulatory disease risks, and their possible mechanisms. Radiat Environ Biophys. 2010;49(2):139–53. doi:10.1007/s00411-009-0250-z [published Online First: Epub Date].
Little MP, Azizova TV, Bazyka D, Bouffler SD, Cardis E, Chekin S, et al. Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks. Environ Health Perspect. 2012;120(11):1503–11. doi:10.1289/ehp.1204982 [published Online First: Epub Date].
McGale P, Darby SC. Low doses of ionizing radiation and circulatory diseases: a systematic review of the published epidemiological evidence. Radiat Res. 2005;163(3):247–57 [published Online First: Epub Date].
Article
CAS
PubMed
Google Scholar
Little MP. A review of non-cancer effects, especially circulatory and ocular diseases. Radiat Environ Biophys. 2013;52(4):435–49. doi:10.1007/s00411-013-0484-7. [published Online First: Epub Date]|.
Article
PubMed Central
PubMed
Google Scholar
Schöllnberger H, Kaiser JC, Jacob P, Walsh L. Dose-responses from multi-model inference for the non-cancer disease mortality of atomic bomb survivors. Radiat Environ Biophys. 2012;51(2):165–78. doi:10.1007/s00411-012-0410-4 [published Online First: Epub Date].
International Commission on Radiological Protection. ICRP statement on tissue reactions and early and late effects of radiation in normal tissues and organs - threshold doses for tissue reactions in a radiation protection context. ICRP publication 118. Ann ICRP. 2012;41(1–2):1–322. doi:10.1016/j.icrp.2007.10.003 [published Online First: Epub Date].
Google Scholar
Schultz-Hector S, Trott KR. Radiation-induced cardiovascular diseases: is the epidemiologic evidence compatible with the radiobiologic data? Int J Radiat Oncol Biol Phys. 2007;67(1):10–8. doi:10.1016/j.ijrobp.2006.08.071 [published Online First: Epub Date].
Article
CAS
PubMed
Google Scholar
Shimizu Y, Kodama K, Nishi N, Kasagi F, Suyama A, Soda M, et al. Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950–2003. BMJ. 2010;340:b5349.
Yamada M, Wong FL, Fujiwara S, Akahoshi M, Suzuki G. Noncancer disease incidence in atomic bomb survivors, 1958–1998. Radiat Res. 2004;161(6):622–32 [published Online First: Epub Date].
Tatsukawa Y, Nakashima E, Yamada M, Funamoto S, Hida A, Akahoshi M, et al. Cardiovascular disease risk among atomic bomb survivors exposed in utero, 1978–2003. Radiat Res. 2008;170(3):269–74. doi:10.1667/RR1434.1 [published Online First: Epub Date].
Ivanov VK, Maksioutov MA, Chekin SY, Petrov AV, Biryukov AP, Kruglova ZG, et al. The risk of radiation-induced cerebrovascular disease in Chernobyl emergency workers. Health Phys. 2006;90(3):199–207. doi:10.1097/01.HP.0000175835.31663.ea [published Online First: Epub Date].
Azizova TV, Haylock RGE, Moseeva MB, Bannikova MV, Grigoryeva ES. Cerebrovascular diseases incidence and mortality in an extended Mayak worker cohort 1948–1982. Radiat Res 2014 doi:10.1667/RR13680.1[published Online First: Epub Date].
Moseeva MB, Azizova TV, Grigoryeva ES, Haylock R. Risks of circulatory diseases among Mayak PA workers with radiation doses estimated using the improved Mayak Worker Dosimetry System 2008. Radiat Environ Biophys. 2014;53(2):469–77. doi:10.1007/s00411-014-0517-x [published Online First: Epub Date].
Stewart AM, Kneale GW. A-bomb survivors: factors that may lead to a re-assessment of the radiation hazard. Int J Epidemiol. 2000;29(4):708–14.
Article
CAS
PubMed
Google Scholar
Little MP. Absence of evidence for differences in the dose–response for cancer and non-cancer endpoints by acute injury status in the Japanese atomic-bomb survivors. Int J Radiat Biol. 2002;78(11):1001–10. doi:10.1080/0955300021000013803 [published Online First: Epub Date].
Article
CAS
PubMed
Google Scholar
Vrijheid M, Cardis E, Ashmore P, Auvinen A, Bae J-M, Engels H, et al. Mortality from diseases other than cancer following low doses of ionizing radiation: results from the 15-Country Study of nuclear industry workers. Int J Epidemiol. 2007;36(5):1126–35. doi:10.1093/ije/dym138 [published Online First: Epub Date].
Travis LB, Hauptmann M, Knudson Gaul L, Storm HH, Goldman MB, Nyberg U, et al. Site-specific cancer incidence and mortality after cerebral angiography with radioactive thorotrast. Radiat Res. 2003;160(6):691–706 [published Online First: Epub Date].
Muirhead CR, O’Hagan JA, Haylock RGE, Phillipson MA, Willcock T, Berridge GLC, et al. Mortality and cancer incidence following occupational radiation exposure: third analysis of the National Registry for Radiation Workers. Br J Cancer. 2009;100(1):206–12. doi:10.1038/sj.bjc.6604825 [published Online First: Epub Date].
Kreuzer M, Kreisheimer M, Kandel M, Schnelzer M, Tschense A, Grosche B. Mortality from cardiovascular diseases in the German uranium miners cohort study, 1946–1998. Radiat Environ Biophys. 2006;45(3):159–66. doi:10.1007/s00411-006-0056-1 [published Online First: Epub Date].
Kreuzer M, Dufey F, Sogl M, Schnelzer M, Walsh L. External gamma radiation and mortality from cardiovascular diseases in the German WISMUT uranium miners cohort study, 1946–2008. Radiat Environ Biophys. 2013;52(1):37–46. doi:10.1007/s00411-012-0446-5 [published Online First: Epub Date].
Lane RSD, Frost SE, Howe GR, Zablotska, LB. Mortality (1950–1999) and cancer incidence (1969–1999) in the cohort of Eldorado uranium workers. Radiat Res. 2010;174(6):773–85. doi:10.1667/RR2237.1 [published Online First: Epub Date].
Laurent O, Metz-Flamant C, Rogel A, Hubert D, Riedel A, Garcier Y, et al. Relationship between occupational exposure to ionizing radiation and mortality at the French electricity company, period 1961–2003. Int Arch Occup Environ Health. 2010;83(8):935–44. doi:10.1007/s00420-010-0509-3 [published Online First: Epub Date].
McGeoghegan D, Binks K, Gillies M, Jones S, Whaley S. The non-cancer mortality experience of male workers at British Nuclear Fuels plc, 1946–2005. Int J Epidemiol. 2008;37(3):506–18. doi:10.1093/ije/dyn018 [published Online First: Epub Date].
Krestinina LY, Epifanova S, Silkin S, Mikryukova L, Degteva M, Shagina N, et al. Chronic low-dose exposure in the Techa River Cohort: risk of mortality from circulatory diseases. Radiat Environ Biophys. 2013;52(1):47–57. doi:10.1007/s00411-012-0438-5 [published Online First: Epub Date].
Grosche B, Lackland DT, Land CE, Simon SL, Apsalikov KN, Pivina LM, et al. Mortality from cardiovascular diseases in the Semipalatinsk historical cohort, 1960–1999, and its relationship to radiation exposure. Radiat Res. 2011;176(5):660–69. doi:10.1667/RR2211.1 [published Online First: Epub Date].
Little MP. Threshold and other departures from linear-quadratic curvature in the non-cancer mortality dose–response curve in the Japanese atomic bomb survivors. Radiat Environ Biophys. 2004;43(2):67–75. doi:10.1007/s00411-004-0244-9 [published Online First: Epub Date].
Article
PubMed
Google Scholar
Preston DL, Shimizu Y, Pierce DA, Suyama A, Mabuchi K. Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950–1997. Radiat Res. 2003;160(4):381–407 [published Online First: Epub Date].
Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Bronnum D, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;368(11):987–98. doi:10.1056/NEJMoa1209825 [published Online First: Epub Date].
Mitchel REJ, Hasu M, Bugden M, Wyatt H, Little MP, Gola A, et al. Low-dose radiation exposure and atherosclerosis in ApoE
−/− mice. Radiat Res. 2011;175(5):665–76. doi:10.1667/RR2176.1 [published Online First: Epub Date].
Little MP, Preston DL, Kitahara CM, Freedman DM, Simon SL, Alexander BH, et al. Circulatory disease mortality after low-dose occupational radiation exposures in US radiologic technologists. Int J Epidemiol 2015 submitted.
Little MP, Zablotska LB, Brenner AV, Lipshultz SE. Circulatory disease mortality in the Massachusetts tuberculosis fluoroscopy cohort study. Eur J Epidemiol 2015 in press. doi:10.1007/s10654-015-0075-9.
Zablotska LB, Little MP, Cornett RJ. Potential increased risk of ischemic heart disease mortality with significant dose fractionation in the Canadian fluoroscopy cohort study. Am J Epidemiol. 2014;179(1):120–31. doi:10.1093/aje/kwt244 [published Online First: Epub Date].
Article
PubMed Central
PubMed
Google Scholar
Kusunoki Y, Kyoizumi S, Hirai Y, Suzuki T, Nakashima E, Kodama K, et al. Flow cytometry measurements of subsets of T, B and NK cells in peripheral blood lymphocytes of atomic bomb survivors. Radiat Res. 1998;150(2):227–36.
Danesh J, Whincup P, Lewington S, Walker M, Lennon L, Thomson A, et al. Chlamydia pneumoniae IgA titres and coronary heart disease - Prospective study and meta-analysis. European Heart Journal. 2002;23(5):371–75. doi:10.1053/euhj.2001.2801 [published Online First: Epub Date].
Ridker PM. Inflammation, infection, and cardiovascular risk: how good is the clinical evidence? Circulation. 1998;97(17):1671–74.
Article
CAS
PubMed
Google Scholar
Whincup P, Danesh J, Walker M, Lennon L, Thomson A, Appleby P, et al. Prospective study of potentially virulent strains of Helicobacter pylori and coronary heart disease in middle-aged men. Circulation. 2000;101(14):1647–52.
Cannon CP, Braunwald E, McCabe CH, Grayston JT, Muhlestein B, Giugliano RP, et al. Antibiotic treatment of Chlamydia pneumoniae after acute coronary syndrome. N Engl J Med. 2005;352(16):1646–54. doi:10.1056/NEJMoa043528 [published Online First: Epub Date].
Grayston JT, Kronmal RA, Jackson LA, Parisi AF, Muhlestein JB, Cohen JD, et al. Azithromycin for the secondary prevention of coronary events. N Engl J Med. 2005;352(16):1637–45. doi:10.1056/NEJMoa043526 [published Online First: Epub Date].
Little MP, Gola A, Tzoulaki I. A model of cardiovascular disease giving a plausible mechanism for the effect of fractionated low-dose ionizing radiation exposure. PLoS Comput Biol. 2009;5(10):e1000539. doi:10.1371/journal.pcbi.1000539 [published Online First: Epub Date].
Article
PubMed Central
PubMed
Google Scholar
Lowe D, Raj K. Premature aging induced by radiation exhibits pro-atherosclerotic effects mediated by epigenetic activation of CD44 expression. Aging Cell. 2014;13(5):900–10. doi:10.1111/acel.12253 [published Online First: Epub Date].
Article
PubMed Central
CAS
PubMed
Google Scholar
Adams MJ, Grant EJ, Kodama K, Shimizu Y, Kasagi F, Suyama A, et al. Radiation dose associated with renal failure mortality: a potential pathway to partially explain increased cardiovascular disease mortality observed after whole-body irradiation. Radiat Res. 2012;177(2):220–28. doi:10.1667/RR2746.1 [published Online First: Epub Date].
Lenarczyk M, Lam V, Jensen E, Fish BL, Su J, Koprowski S, et al. Cardiac injury after 10 Gy total body irradiation: indirect role of effects on abdominal organs. Radiat Res. 2013;180(3):247–58. doi:10.1667/RR3292.1 [published Online First: Epub Date].
Creager MA, Lüscher TF, Cosentino F, Beckman JA. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I. Circulation. 2003;108(12):1527–32. doi:10.1161/01.CIR.0000091257.27563.32 [published Online First: Epub Date].
Mulrooney DA, Yeazel MW, Kawashima T, Mertens AC, Mitby P, Stovall M, et al. Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort. BMJ. 2009;339:b4606.
Little MP, Kleinerman RA, Stovall M, Smith SA, Mabuchi K. Analysis of dose response for circulatory disease after radiotherapy for benign disease. Int J Radiat Oncol Biol Phys. 2012;84(5):1101–09. doi:10.1016/j.ijrobp.2012.01.053 [published Online First: Epub Date].
Kleinerman RA, Weinstock RM, Mabuchi K. High-dose abdominal radiotherapy and risk of diabetes mellitus. Arch Intern Med. 2010;170(16):1506–07. doi:10.1001/archinternmed.2010.285 [published Online First: Epub Date].
Article
PubMed
Google Scholar
van Nimwegen FA, Schaapveld M, Janus CPM, Krol ADG, Raemaekers JMM, Kremer LCM, et al. Risk of diabetes mellitus in long-term survivors of Hodgkin lymphoma. J Clin Oncol. 2014;32(29):3257–63. doi:10.1200/JCO.2013.54.4379 [published Online First: Epub Date].
de Vathaire F, El-Fayech C, Ben Ayed FF, Haddy N, Guibout C, Winter D, et al. Radiation dose to the pancreas and risk of diabetes mellitus in childhood cancer survivors: a retrospective cohort study. Lancet Oncol. 2012;13(10):1002–10. doi:10.1016/S1470-2045(12)70323-6 [published Online First: Epub Date].
Belsky JL, Tachikawa K, Jablon S. The health of atomic bomb survivors: a decade of examinations in a fixed population. Yale J Biol Med. 1973;46(4):284–96.
PubMed Central
CAS
PubMed
Google Scholar
Fujiwara S, Sposto R, Shiraki M, Yokoyama N, Sasaki H, Kodama K, et al. Levels of parathyroid hormone and calcitonin in serum among atomic bomb survivors. Radiat Res. 1994;137(1):96–103.
Andersson P, Rydberg E, Willenheimer R. Primary hyperparathyroidism and heart disease--a review. Eur Heart J. 2004;25(20):1776–87. doi:10.1016/j.ehj.2004.07.010 [published Online First: Epub Date].
Article
CAS
PubMed
Google Scholar
Richardson DB, Wing S. Radiation and mortality of workers at Oak Ridge National Laboratory: positive associations for doses received at older ages. Environ Health Perspect. 1999;107(8):649–56 [published Online First: Epub Date].
Article
PubMed Central
CAS
PubMed
Google Scholar
Talbott EO, Youk AO, McHugh-Pemu KP, Zborowski JV. Long-term follow-up of the residents of the Three Mile Island accident area: 1979–1998. Environ Health Perspect. 2003;111(3):341–48.